About: Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis

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About: Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis
Creator	Lamontagne, Lucie Samson, Michel Carrière, Virginie Chalmel, Frédéric Farooq, Muhammad Gascan, Hugues Genet, Valentine Girard, Jean-Philippe Jan, Aurélien Le Seyec, Jacques Lefevre, Benjamin Lucas-Clerc, Catherine Manuel, Christelle Piquet-Pellorce, Claire Touami-Bernard, Laurence Arshad, Muhammad
Source	Medline; PMC
abstract	The alarmin IL-33 has been described to be upregulated in human and murine viral hepatitis. However, the role of endogenous IL-33 in viral hepatitis remains obscure. We aimed to decipher its function by infecting IL-33-deficient mice (IL-33 KO) and their wild-type (WT) littermates with pathogenic mouse hepatitis virus (L2-MHV3). The IL-33 KO mice were more sensitive to L2-MHV3 infection exhibiting higher levels of AST/ALT, higher tissue damage, significant weight loss, and earlier death. An increased depletion of B and T lymphocytes, NKT cells, dendritic cells, and macrophages was observed 48 h postinfection (PI) in IL-33 KO mice than that in WT mice. In contrast, a massive influx of neutrophils was observed in IL-33 KO mice at 48 h PI. A transcriptomic study of inflammatory and cell-signaling genes revealed the overexpression of IL-6, TNFα, and several chemokines involved in recruitment/activation of neutrophils (CXCL2, CXCL5, CCL2, and CCL6) at 72 h PI in IL-33 KO mice. However, the IFNγ was strongly induced in WT mice with less profound expression in IL-33 KO mice demonstrating that endogenous IL-33 regulated IFNγ expression during L2-MHV3 hepatitis. In conclusion, we demonstrated that endogenous IL-33 had multifaceted immunoregulatory effect during viral hepatitis via induction of IFNγ, survival effect on immune cells, and infiltration of neutrophils in the liver.
has issue date	2017-05-04(xsd:dateTime)
bibo:doi	10.1155/2017/1359064
bibo:pmid	28607531
has license	cc-by
sha1sum (hex)	bb61dcfd20c7d56e90a52779d3f51a1f68c46362
schema:url	https://doi.org/10.1155/2017/1359064
resource representing a document's title	Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis
has PubMed Central identifier	PMC5457781
has PubMed identifier	28607531
schema:publication	Mediators Inflamm
resource representing a document's body	covid:bb61dcfd20c7d56e90a52779d3f51a1f68c46362#body_text
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