About: Transmission in the Guinea Pig Model

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transmission in the Guinea Pig Model
Creator	Steel, John Bouvier, Nicole Lowen, Anice
Source	PMC
abstract	The ability of an influenza virus to transmit efficiently from human-to-human is a major factor in determining the epidemiological impact of that strain. The use of a relevant animal model to identify viral determinants of transmission, as well as host and environmental factors affecting transmission efficiency, is therefore critical for public health. The characterization of newly emerging influenza viruses in terms of their potential to transmit in a mammalian host is furthermore an important part of pandemic risk assessment. For these reasons, a guinea pig model of influenza virus transmission was developed in 2006. The guinea pig provides an important alternative to preexisting models for influenza. Most influenza viruses do not readily transmit among mice. Ferrets, while highly relevant, are expensive and can be difficult to obtain in high numbers. Moreover, it is generally accepted that efforts to accurately model human disease are strengthened by the use of multiple animal species. Herein, we provide an overview of influenza virus infectivity, growth, and transmission in the guinea pig and highlight knowledge gained on the topic of influenza virus transmission using the guinea pig model.
has issue date	2014-07-08(xsd:dateTime)
bibo:doi	10.1007/82_2014_390
bibo:pmid	25001209
has license	no-cc
sha1sum (hex)	bb628bb5dee0ced2b4c45420794bdf6dd2aeee04
schema:url	https://doi.org/10.1007/82_2014_390
resource representing a document's title	Transmission in the Guinea Pig Model
has PubMed Central identifier	PMC7121145
has PubMed identifier	25001209
schema:publication	Influenza Pathogenesis and Control - Volume I
resource representing a document's body	covid:bb628bb5dee0ced2b4c45420794bdf6dd2aeee04#body_text
is schema:about of	named entity 'IS A' named entity 'epidemiological' named entity 'determining' named entity 'factor' named entity 'epidemiological' named entity 'Guinea Pig' named entity '2009 pandemic' named entity 'oseltamivir' named entity '2009 pandemic' named entity 'viruses' named entity 'mucosal surfaces' named entity 'viruses' named entity 'galactose' named entity 'intranasal' named entity 'antibody' named entity 'interferon' named entity 'influenza virus' named entity 'serial passage' named entity 'sialic acids' named entity 'rhinitis' named entity 'highly pathogenic avian influenza' named entity 'guinea pigs' named entity 'H7N9' named entity 'epithelia' named entity 'wild-type' named entity 'ID50' named entity 'ferret' named entity 'respiratory tract' named entity 'reassorted' named entity 'mice' named entity 'gene' named entity 'guinea pigs' named entity 'influenza vaccines' named entity 'influenza viruses' named entity 'guinea pigs' named entity 'influenza virus' named entity 'glycans' named entity 'infection' named entity 'respiratory droplet' named entity 'treatment group' named entity 'H3N2' named entity 'guinea pigs' named entity 'influenza virus' named entity 'influenza virus' named entity 'genomes' named entity 'isotype' named entity 'viruses' named entity 'serum' named entity 'mammals' named entity 'influenza virus' named entity 'oseltamivir' named entity 'H1 hemagglutinin' named entity 'guinea pigs' named entity 'mutation' named entity 'morbidity' named entity 'preclinical development' named entity 'guinea pigs' named entity 'infection' named entity 'reverse genetics' named entity 'H9N2' named entity 'H5N1' named entity 'avian influenza viruses' named entity 'homologous' named entity 'seasonal influenza' named entity 'lower respiratory tract' named entity 'infection' named entity 'guinea pig' named entity 'Wuhan' named entity 'infection' named entity 'animal models' named entity 'sialylated' named entity 'guinea pigs' named entity 'guinea pigs' named entity 'guinea pigs' named entity 'viruses' named entity 'guinea pigs' named entity 'reassortant' named entity 'lung' named entity 'sialylated'

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