About: Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19
Creator	Chen, Feng Zhang, Lei Chang, Christopher Wang, Junyi He, Xiang Li, Guoping Ran, Qin Wu, Dehong Xiong, Anying Sun, Jinlyu
Source	Elsevier; Medline; PMC
abstract	Abstract It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of ACE2 may therefore help reveal underlying mechanisms of viral susceptibility and post-infection modulation. In this study, we utilized previously uploaded information on ACE2 expression in various conditions including SARS-CoA to evaluate the role of ACE2 in SARS-CoV and extrapolate that to COVID-19. We found that the expression of ACE2 in healthy populations and patients with underlying diseases was not significantly different. However, based on the elevated expression of ACE2 in cigarette smokers, we speculate that long-term smoking may be a risk factor for COVID-19. Analysis of ACE2 in SARS-CoV infected cells suggests that ACE2 is not only a receptor but is also involved in post-infection regulation, including immune response, cytokine secretion, and viral genome replication. Moreover, we constructed Protein-protein interaction (PPI) networks and identified hub genes in viral activity and cytokine secretion. Our findings may help clinicians and researchers gain more insight into the pathogenesis of SARS-CoV-2 and design therapeutic strategies for COVID-19.
has issue date	2020-04-13(xsd:dateTime)
bibo:doi	10.1016/j.jaut.2020.102463
bibo:pmid	32303424
has license	els-covid
sha1sum (hex)	bbcd236d80bd22184d7a79b6df168a72704572b0
schema:url	https://doi.org/10.1016/j.jaut.2020.102463
resource representing a document's title	Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19
has PubMed Central identifier	PMC7152872
has PubMed identifier	32303424
schema:publication	J Autoimmun
resource representing a document's body	covid:bbcd236d80bd22184d7a79b6df168a72704572b0#body_text
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