About: Update on Bronchiolitis Obliterans Syndrome in Lung Transplantation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Update on Bronchiolitis Obliterans Syndrome in Lung Transplantation
Creator	Lin, Christine Zamora, Martin
source	Medline; PMC
abstract	Lung transplantation has become an important therapeutic option for patients with end-stage organ dysfunction; however, its clinical usefulness has been limited by the relatively early onset of chronic allograft dysfunction and progressive clinical decline. Obliterative bronchiolitis is characterized histologically by luminal fibrosis of the respiratory bronchioles and clinically by bronchiolitis obliterans syndrome (BOS) which is defined by a measured decline in lung function based on forced expiratory volume (FEV(1)). Since its earliest description, a number of risk factors have been associated with the development of BOS, including acute rejection, lymphocytic bronchiolitis, primary graft dysfunction, infection, donor specific antibodies, and gastroesophageal reflux disease. However, despite this broadened understanding, the pathogenesis underlying BOS remains poorly understood and once begun, there are relatively few treatment options to battle the progressive deterioration in lung function.
has issue date	2014-09-12(xsd:dateTime)
bibo:doi	10.1007/s40472-014-0030-9
bibo:pmid	32226712
has license	no-cc
sha1sum (hex)	bbd65ef4c57479d540671a05723aae4c9e411ae2
schema:url	https://doi.org/10.1007/s40472-014-0030-9
resource representing a document's title	Update on Bronchiolitis Obliterans Syndrome in Lung Transplantation
has PubMed Central identifier	PMC7100813
has PubMed identifier	32226712
schema:publication	Curr Transplant Rep
resource representing a document's body	covid:bbd65ef4c57479d540671a05723aae4c9e411ae2#body_text
is schema:about of	named entity 'risk factors' named entity 'primary' named entity 'defined' named entity 'bronchiolitis' named entity 'respiratory bronchioles' named entity 'Lung transplantation' named entity 'lung function' named entity 'donor' named entity 'organ dysfunction' named entity 'histologically' named entity 'Obliterative bronchiolitis' named entity 'end-stage' named entity 'luminal' named entity 'treatment options' named entity 'primary graft dysfunction' named entity 'acute rejection' named entity 'risk factors' named entity 'lung function' named entity 'calcineurin inhibitor' named entity 'immunosuppressive' named entity 'granulation tissue' named entity 'donor-specific antibodies' named entity 'necrosis' named entity 'long-term' named entity 'IL-12' named entity 'ultraviolet' named entity 'heterogeneic' named entity 'extracorporeal photopheresis' named entity 'IL-2' named entity 'Airway' named entity 'chronic rejection' named entity 'allograft' named entity 'Animal Rights' named entity 'fungal infections' named entity 'bronchiolitis' named entity 'organ' named entity 'neutrophilia' named entity 'pulmonary function tests' named entity 'heterogeneity' named entity 'lung function' named entity 'submucosa' named entity 'forced expiratory flow' named entity 'revascularization' named entity 'UNOS' named entity 'solid organ transplants' named entity 'scar tissue' named entity 'tacrolimus' named entity 'bronchial artery' named entity 'clinical diagnostic' named entity 'clarithromycin' named entity 'PGD' named entity 'retrospective study' named entity 'esophagogastroduodenoscopy' named entity '5-year survival' named entity 'bronchial hyperresponsiveness' named entity 'murine' named entity 'Antibodies' named entity 'long-term' named entity 'institutional review boards' named entity 'Type V collagen' named entity 'forced expiratory volume' named entity 'air-trapping' named entity 'PRA' named entity 'FEV' named entity 'cystic fibrosis' named entity 'allograft' named entity 'infection' named entity 'HLA antigens' named entity 'GERD' named entity 'panel reactive antibody' named entity 'allograft' named entity 'immunosuppression' named entity 'GERD' named entity 'exhaled nitric oxide' named entity 'etiology' named entity 'infection' named entity 'cyclophosphamide' named entity 'obliterative bronchiolitis' named entity 'vasculature' named entity 'acute rejection'

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