About: Dynamic profile of RT-PCR findings from 301 COVID-19 patients in Wuhan, China: a descriptive study

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamic profile of RT-PCR findings from 301 COVID-19 patients in Wuhan, China: a descriptive study
Creator	Zhang, Yu Zhang, Sheng Zhu, Li Gao, Chun Tang, Ai Tong, Tong, Yi Yi, Xin
Source	Elsevier; Medline; PMC
abstract	Abstract Background With the spread of Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection, its effect on society is amplified. We aimed to describe the viral detection results across different timepoints throughout the disease course. Methods A retrospective study of 301 confirmed COVID-19 patients hospitalized at Tongji Hospital in Wuhan, China, were included. Demographic characteristics of the patients were collected. Upper respiratory specimens (throat and/or nasal swabs) were obtained and analyzed by real-time RT-PCR for SARS-CoV-2 infection. Period of viral infection and the contagious stage were analyzed. Results Of 301 hospitalized COVID-19 patients, the median age was 58 years and 51.2% were male. The median period between symptoms presence and positive SARS-CoV-2 RT-PCR results was 16 days (IQR, 10-23, N = 301). The median period between symptoms presence and an effective negative SARS-CoV-2 RT-PCR result was 20 days (IQR, 17-24; N = 216). Infected patient ≥65 years old stayed contagious longer (22 days vs 19 days, p = 0.015). Although two consecutive negative results were confirmed in 70 patients, 30% of them had positive viral test results for the third time. Using specimens from nasal swabs to run the RT-PCR test showed a higher positive rate than using specimens from throat swabs. Conclusions This large-scale investigation with 1113 RT-PCR test results from 301 COVID-19 patients showed that the average contagious period of SARS-CoV-2 infected patients was 20 days. Longer observation period and more than 2 series of negative viral test are necessary for patients ≥65 years.
has issue date	2020-04-11(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2020.104346
bibo:pmid	32361324
has license	els-covid
sha1sum (hex)	bbda64bc03cf420c886826a11264b1e1c5311875
schema:url	https://doi.org/10.1016/j.jcv.2020.104346
resource representing a document's title	Dynamic profile of RT-PCR findings from 301 COVID-19 patients in Wuhan, China: a descriptive study
has PubMed Central identifier	PMC7151472
has PubMed identifier	32361324
schema:publication	J Clin Virol
resource representing a document's body	covid:bbda64bc03cf420c886826a11264b1e1c5311875#body_text
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