About: Elevated Plasma Surfactant Protein D (SP‐D) Levels and a Direct Correlation with Anti‐severe Acute Respiratory Syndrome Coronavirus‐specific IgG Antibody in SARS Patients

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About: Elevated Plasma Surfactant Protein D (SP‐D) Levels and a Direct Correlation with Anti‐severe Acute Respiratory Syndrome Coronavirus‐specific IgG Antibody in SARS Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Elevated Plasma Surfactant Protein D (SP‐D) Levels and a Direct Correlation with Anti‐severe Acute Respiratory Syndrome Coronavirus‐specific IgG Antibody in SARS Patients
Creator	Zhang, F Wu, Y Xu, W Han, J Chen-, B De Groot, P Holmskov, U Liuà, Z Mao, N Pan, S Reidàà, K Sorensen, G Wei, R Xia, Z
source	Medline; PMC
abstract	Pulmonary SP‐D is a defence lectin promoting clearance of viral infections. SP‐D is recognized to bind the S protein of SARS‐CoV and enhance phagocytosis. Moreover, systemic SP‐D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP‐D, SARS‐type pneumonia and the SARS‐specific IgG response. Sixteen patients with SARS, 19 patients with community‐acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP‐D and anti‐SARS‐CoV N protein IgG were measured using ELISA. SP‐D was significantly elevated in SARS‐type pneumonia [median (95% CI), 453 (379–963) ng/ml versus controls 218 (160–362) ng/ml, P < 0.05] like in patients with CAP. SP‐D significantly correlated with anti‐SARS‐CoV N protein IgG (r (2) = 0.5995, P = 0.02). The possible re‐emergence of SARS or SARS‐like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP‐D may be useful in monitoring the alveolar integrity in SARS‐type pneumonia. The significant correlation between plasma SP‐D and anti‐SARS‐CoV‐specific antibodies support the role for SP‐D in interlinking innate and adaptive immune pathways.
has issue date	2009-03-19(xsd:dateTime)
bibo:doi	10.1111/j.1365-3083.2009.02245.x
bibo:pmid	19439011
has license	no-cc
sha1sum (hex)	bbdd43b3ae1236960f06141765d38ee7e9582d5e
schema:url	https://doi.org/10.1111/j.1365-3083.2009.02245.x
resource representing a document's title	Elevated Plasma Surfactant Protein D (SP‐D) Levels and a Direct Correlation with Anti‐severe Acute Respiratory Syndrome Coronavirus‐specific IgG Antibody in SARS Patients
has PubMed Central identifier	PMC7169533
has PubMed identifier	19439011
schema:publication	Scand J Immunol
resource representing a document's body	covid:bbdd43b3ae1236960f06141765d38ee7e9582d5e#body_text
is schema:about of	named entity 'pneumonia' named entity 'alveolar' named entity 'Pulmonary' named entity 'patients' named entity 'biomarker' named entity 'integrity' named entity 'SP-D' named entity 'IgG' named entity 'Surfactant Protein D' named entity 'INVESTIGATED' named entity 'SUGGEST' named entity 'LIKE' named entity 'PNEUMONIA' named entity 'alveolar' named entity 'control' named entity 'SP-D' named entity 'minimal' named entity 'systemic' named entity 'SP-D' named entity 'protein' named entity 'infections' named entity 'adaptive immune' named entity 'SP-D' named entity 'antibodies' named entity 'SARS-CoV' named entity 'biomarker' named entity 'pneumonia' named entity 'SP-D' named entity 'SARS' named entity 'SP-D' named entity 'SARS' named entity 'control subjects' named entity 'adaptive immune' named entity 'SARS' named entity 'plasma' named entity 'Antibody' named entity 'SARS' named entity 'hybridomas' named entity 'SP-D' named entity 'correlation' named entity 'systolic blood pressure' named entity 'SARS-CoV' named entity 'pneumonia' named entity 'coagulation' named entity 'seroconversion' named entity 'expression vector' named entity 'glycoprotein' named entity 'protein' named entity 'SARS-CoV' named entity 'plasma' named entity 'immune mechanisms' named entity 'TRIzol' named entity 'cell cycle' named entity 'thrombocytosis' named entity 'SARS' named entity 'SARS' named entity 'SARS' named entity 'SARS' named entity 'thrombocytosis' named entity 'SP-D' named entity 'Atlanta' named entity 'recombinant' named entity 'antigen' named entity 'alveolar' named entity 'agglutination' named entity 'ELISA assay' named entity 'pneumonia' named entity 'SP-D'

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