About: Clinical evaluation of fully automated molecular diagnostic system “Simprova” for influenza virus, respiratory syncytial virus, and human metapneumovirus

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About: Clinical evaluation of fully automated molecular diagnostic system “Simprova” for influenza virus, respiratory syncytial virus, and human metapneumovirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical evaluation of fully automated molecular diagnostic system “Simprova” for influenza virus, respiratory syncytial virus, and human metapneumovirus
Creator	Saito, Shinji Takayama, Ikuyo Kaida, Atsushi Kubo, Hideyuki Asai, Sadasaburo Shiomi, Masashi Nakauchi, Mina Oba, Kunihiro Semba, Shohei Kaji, Katsushi Kiya, Keiichi Murakami, Kiyotaka Sawada, Yoshitaka Segawa, Yuji Terada, Akihiro Tsutomu Kageyama, & Watanabe, Hidetoshi Yokono, Kota
Source	PMC
abstract	Influenza virus, respiratory syncytial virus, and human metapneumovirus commonly cause acute upper and lower respiratory tract infections, especially in children and the elderly. Although rapid antigen detection tests for detecting these infections have been introduced recently, these are less sensitive than nucleic acid amplification tests. More recently, highly sensitive point-of-care testings (POCTs) have been developed based on nucleic acid amplification tests, which are easy to use in clinical settings. In this study, loop-mediated isothermal amplification (LAMP)-based POCT “Simprova” to detect influenza A and B viruses, respiratory syncytial virus, and human metapneumovirus was developed. Simprova system is fully automated and does not require skilled personnel. In addition, positive results can be achieved faster than with PCR. In this study, the accuracy of the POCT was retrospectively analyzed using 241 frozen stocked specimens. Additionally, the usability of the Simprova at clinical sites was assessed in a prospective clinical study using 380 clinical specimens and compared to those of real-time PCR and rapid antigen detection test. The novel LAMP-based POCT demonstrated high sensitivity and specificity in characterizing clinical specimens from patients with influenza-like illnesses. The Simprova is a powerful tool for early diagnosis of respiratory viral infections in point-of-care settings.
has issue date	2020-08-11(xsd:dateTime)
bibo:doi	10.1038/s41598-020-70090-2
bibo:pmid	32782312
has license	cc-by
sha1sum (hex)	bbe20d9462fad12185d190622825fa139d36091d
schema:url	https://doi.org/10.1038/s41598-020-70090-2
resource representing a document's title	Clinical evaluation of fully automated molecular diagnostic system “Simprova” for influenza virus, respiratory syncytial virus, and human metapneumovirus
has PubMed Central identifier	PMC7419501
has PubMed identifier	32782312
schema:publication	Sci Rep
resource representing a document's body	covid:bbe20d9462fad12185d190622825fa139d36091d#body_text
is schema:about of	named entity 'Influenza virus' named entity 'acid' named entity 'loop-mediated isothermal amplification' named entity 'assessed' named entity 'acid' named entity 'ELDERLY' named entity 'TESTS' named entity 'PATIENTS' named entity 'NOVEL' named entity 'PERSONNEL' named entity 'TOOL' named entity 'SETTINGS' named entity 'TEST' named entity 'RECENTLY' named entity 'SPECIMENS' covid:arg/bbe20d9462fad12185d190622825fa139d36091d named entity 'powerful' named entity 'point-of-care' named entity 'sensitive' named entity 'amplification' named entity 'patients' named entity 'system' named entity 'sensitive' named entity 'frozen' named entity 'human metapneumovirus' named entity 'upper' named entity 'detect' named entity 'respiratory syncytial virus' named entity 'lower respiratory tract infections' named entity 'POCT' named entity 'POCT' named entity 'nucleic acid amplification tests' named entity 'clinical study' named entity 'antigen' named entity 'nucleic acid amplification tests' named entity 'Thermo Fisher Scientific' named entity 'flowchart' named entity 'viscous' named entity 'RT-PCR' named entity 'Boston' named entity 'RADT' named entity 'pediatric patients' named entity 'cDNA' named entity 'clinical study' named entity 'Qiagen' named entity 'incubation' named entity 'rPCR' named entity 'MedCalc' named entity 'RNA' named entity 'systematic reviews' named entity 'Germany' named entity 'influenza-like' named entity 'PCR' named entity 'nucleic acid' named entity 'global epidemics' named entity 'IBV' named entity 'transport medium' named entity 'IAV' named entity 'sensitivity and specificity' named entity 'LODs' named entity 'normal saline' named entity 'Genbank' named entity 'LOD' named entity 'LOD'

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