About: Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China

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About: Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China
Creator	Xiong, Yong Chen, Tie-Long Deng, Li-Ping Gao, Shi-Cheng Hu, Wen-Jia Ma, Zhi-Yong Mo, Ping-Zheng Song, Shi-Hui Zhang, Yong-Xi
Source	Medline; PMC
abstract	BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection because of the immunosuppressive state cause by therapies on tumors. CASE PRESENTATION: We present the clinical features of four cancer patients who were infected with SARS-CoV-2 in late January of 2020 in our hospital. Cases 1 and 3 were diagnosed as mild and common type of coronavirus disease 2019 (COVID-2019) and survived from the viral infection. They acquired SARS-CoV-2 infection during their staying in hospital under radiotherapy and surgery of the tumors. Cases 2 and 4 suffered from severe type of COVID-19, and Case 2 was dead owning to the advanced age, uncontrolled chronic B cell lymphocytic leukemia and many other underlying diseases. The immunosuppressive state induced by liver transplantation and anti-rejection therapy might contribute to the severity of COVID-19 in Case 4, who suffered from hepatitis B related hepatocellular carcinoma. However, Case 4 was recovered from COVID-19 after a combination therapy against virus, bacteria and fungi, and also respiratory support. Nearly all patients showed a decrease in lymphocytes including total CD3(+) T cells, B cells, and natural killer cells after infection of the virus. CONCLUSIONS: The severity of COVID-19 might be influenced by immune system state and underlying diseases in cancer patients. And the treatment of SARS-CoV-2 infection in cancer patients is challenged by the immunosuppressive state of these patients under chemotherapy or surgery.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1186/s40249-020-00707-1
bibo:pmid	32616030
has license	cc-by
sha1sum (hex)	bbe48aa4a52aaca420cd6ad09ce6789d80dc7638
schema:url	https://doi.org/10.1186/s40249-020-00707-1
resource representing a document's title	Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China
has PubMed Central identifier	PMC7330531
has PubMed identifier	32616030
schema:publication	Infect Dis Poverty
resource representing a document's body	covid:bbe48aa4a52aaca420cd6ad09ce6789d80dc7638#body_text
is schema:about of	named entity 'patients' named entity 'diseases' named entity 'type' named entity 'chronic' named entity 'induced' named entity 'SARS-CoV-2' named entity 'UNDERLYING' named entity 'SUPPORT' named entity 'TREATMENT' named entity '2019' named entity 'THEIR' named entity 'TOTAL' named entity 'FUNGI' named entity 'T cells' named entity 'respiratory' named entity 'immunosuppressive' named entity 'radiotherapy' named entity 'cancer' named entity 'immunosuppressive' named entity 'COVID-19' named entity 'recovered' named entity 'liver transplantation' named entity 'Case' named entity 'tumors' named entity 'late' named entity 'lymphocytic' named entity 'lymphocytic leukemia' named entity 'lymphocytes' named entity 'immunosuppressive' named entity 'natural killer cells' named entity 'infection' named entity 'SARS-CoV-2' named entity 'infection' named entity 'combination therapy' named entity 'Wuhan' named entity 'coronavirus disease 2019' named entity 'COVID-19' named entity 'virus' named entity 'COVID' named entity 'infection' named entity 'hepatitis' named entity 'clinical practice' named entity 'pulmonary infection' named entity 'lungs' named entity 'COVID-19 disease' named entity 'clinical outcomes' named entity 'dyspnea' named entity 'oseltamivir' named entity 'Wuhan' named entity 'fever' named entity 'antibiotic therapy' named entity 'WBCs' named entity 'combination therapy' named entity 'cilastatin' named entity 'liver' named entity 'dyspnea' named entity 'positively correlated' named entity 'CT scan' named entity 'SARS-CoV-2' named entity 'clinical diagnosis' named entity 'lymphopenia' named entity 'cytolytic T cells' named entity 'doxorubicin' named entity 'oxygen' named entity 'lymphocytes' named entity 'polyglucosan' named entity 'IFN-γ' named entity 'coronavirus' named entity 'humidification' named entity 'B-CLL' named entity 'combination therapy' named entity 'infection' named entity 'hepatic'

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