About: Cellular entry of the porcine epidemic diarrhea virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cellular entry of the porcine epidemic diarrhea virus
Creator	He, Qigai Rottier, Peter Bosch, Berend-Jan Li, Wentao Van Kuppeveld, Frank
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine epidemic diarrhea virus (PEDV), a coronavirus discovered more than 40 years ago, regained notoriety recently by its devastating outbreaks in East Asia and the Americas, causing substantial economic losses to the swine husbandry. The virus replicates extensively and almost exclusively in the epithelial cells of the small intestine resulting in villus atrophy, malabsorption and severe diarrhea. Cellular entry of this enveloped virus is mediated by the large spike (S) glycoprotein, trimers of which mediate virus attachment to the target cell and subsequent membrane fusion. The S protein has a multidomain architecture and has been reported to bind to carbohydrate (sialic acid) and proteinaceous (aminopeptidase N) cell surface molecules. PEDV propagation in vitro requires the presence of trypsin(-like) proteases in the culture medium, which capacitates the fusion function of the S protein. Here we review the current data on PEDV entry into its host cell, including therein our new observations regarding the functional role of the sialic acid binding activity of the S protein in virus infection. Moreover, we summarize the recent progress on the proteolytic activation of PEDV S proteins, and discuss factors that may determine tissue tropism of PEDV in vivo.
has issue date	2016-12-02(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2016.05.031
bibo:pmid	27317167
has license	els-covid
sha1sum (hex)	bc1abf379b4c3809f3a77e17b7e7193e677d7d31
schema:url	https://doi.org/10.1016/j.virusres.2016.05.031
resource representing a document's title	Cellular entry of the porcine epidemic diarrhea virus
has PubMed Central identifier	PMC7114534
has PubMed identifier	27317167
schema:publication	Virus Research
resource representing a document's body	covid:bc1abf379b4c3809f3a77e17b7e7193e677d7d31#body_text
is schema:about of	named entity 'SEVERE DIARRHEA' named entity 'FUSION' named entity 'ENTRY' named entity 'AMERICAS' named entity 'SWINE' named entity 'PRESENCE OF' named entity 'GLYCOPROTEIN' named entity 'MEDIATED' named entity 'SUBSEQUENT' named entity 'SMALL INTESTINE' named entity 'ATROPHY' named entity 'VIRUS' named entity 'CULTURE MEDIUM' named entity 'YEARS' named entity 'PROPAGATION' named entity 'ALMOST' named entity 'CELLULAR' named entity 'MEDIATE' named entity 'CORONAVIRUS' named entity 'ECONOMIC' named entity 'TO BIND TO' named entity 'MORE THAN' named entity 'EAST ASIA' named entity 'RESULTING IN' named entity 'LARGE' named entity 'REPLICATES' named entity 'LIKE' named entity 'IN VITRO' named entity 'REPORTED' named entity 'ARCHITECTURE' named entity 'ENVELOPED VIRUS' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MALABSORPTION' named entity 'ITS' named entity 'CARBOHYDRATE' named entity 'ACID' named entity 'RECENTLY' named entity 'PROTEINACEOUS' named entity 'S PROTEIN' named entity 'CAUSING' named entity 'VIRUS ATTACHMENT' named entity 'AGO' named entity 'PROTEIN ' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'PROTEASES' named entity 'TARGET CELL' named entity 'OUTBREAKS' named entity 'EPITHELIAL CELLS' named entity 'VILLUS' named entity 'SPIKE' named entity 'TRYPSIN' named entity 'FUNCTION' named entity 'MEMBRANE FUSION' named entity '28S' named entity 'CELLULAR' named entity 'ENTRY' named entity 'CELL SURFACE MOLECULES' named entity 'PEDV' named entity 'virus' named entity 'Americas' named entity 'protein' named entity 'Porcine epidemic diarrhea virus' named entity 'culture medium' named entity 'coronavirus' named entity 'PEDV' named entity 'porcine epidemic diarrhea virus' named entity 'coronavirus' named entity 'N-terminal region' named entity 'PEDV' named entity 'binding activity' named entity 'mass spectrometry' named entity 'infection' named entity 'membrane glycoprotein' named entity 'erythrocytes' named entity 'PEDV' named entity 'Gammacoronavirus' named entity 'epitopes'

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