About: B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

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About: B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase
Creator	Varki, Ajit Diaz, Sandra Pillai, Shiv Varki, Nissi Boboila, Cristian Cariappa, Annaiah Connole, Michelle Haider, Khaleda Kalloo, Geetika Liu, Haoyuan Shi, Hai Takematsu, Hiromu
Source	Medline; PMC
abstract	We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of α2–6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposits. The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling. These results describe a novel catalytic regulator of B cell signaling and underscore the crucial role of inhibitory signaling in the maintenance of immunological tolerance in the B lineage.
has issue date	2009-01-19(xsd:dateTime)
bibo:doi	10.1084/jem.20081399
bibo:pmid	19103880
has license	cc-by-nc-sa
sha1sum (hex)	bc1be3a1d139d15076497fd3d872bd7b5b6fba82
schema:url	https://doi.org/10.1084/jem.20081399
resource representing a document's title	B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase
has PubMed Central identifier	PMC2626685
has PubMed identifier	19103880
schema:publication	J Exp Med
resource representing a document's body	covid:bc1be3a1d139d15076497fd3d872bd7b5b6fba82#body_text
is schema:about of	named entity 'hydroxylase' named entity 'esterase' named entity 'peripheral' named entity 'SIALIC ACID' named entity 'immunoreceptor tyrosine-based inhibitory motif' named entity 'Siae' named entity 'esterase' named entity 'ITIM' named entity 'marginal zone' named entity 'BCR' named entity 'CMAH' named entity 'B cell antigen receptor' named entity 'BCR' named entity 'cations' named entity 'Siae' named entity 'Rag-1' named entity 'B-1 B cell' named entity 'transgenic mice' named entity 'staining' named entity 'CD22' named entity 'BSA' named entity 'enzyme' named entity 'acetylated' named entity 'BCR' named entity 'autoimmune disease' named entity 'Fc portion' named entity 'cross-linking' named entity 'ester' named entity 'immunogen' named entity 'secretion' named entity 'Hepes' named entity 'immunological tolerance' named entity 'PBS' named entity 'Siae' named entity 'loss-of-function' named entity 'vertebrate' named entity 'sialic acid' named entity 'epitope' named entity 'null mice' named entity 'Siae' named entity 'Ig superfamily' named entity 'sialic acid' named entity 'biological role' named entity 'Bio-Rad Laboratories' named entity 'antibodies' named entity 'glycans' named entity 'PBS' named entity 'IgG2b' named entity 'BCR' named entity 'acetylation' named entity 'blocking antibody' named entity 'protein' named entity 'CD33' named entity 'N-glycans' named entity 'Rag-1' named entity 'polystyrene' named entity 'CD72' named entity 'ligation' named entity 'BCR' named entity 'CD22' named entity 'CD22' named entity 'sialic acid' named entity 'cell surface' named entity 'null mice' named entity 'Src' named entity 'C57BL/6' named entity 'digestion' named entity 'CD21' named entity 'The Jackson Laboratory' named entity 'CD22'

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