About: Overexpression of fibrinogen-like protein 2 induces epithelial-to-mesenchymal transition and promotes tumor progression in colorectal carcinoma

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About: Overexpression of fibrinogen-like protein 2 induces epithelial-to-mesenchymal transition and promotes tumor progression in colorectal carcinoma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Overexpression of fibrinogen-like protein 2 induces epithelial-to-mesenchymal transition and promotes tumor progression in colorectal carcinoma
Creator	Chen, Wei-Feng He, Jiang Li, • Cai, Ming-Yan Hu, Jian-Wei Li, Quan-Lin Ma, Li-Li Meng-, • Qin, Wen-Zheng Xu, Mei-Dong Yao, -Qing Zhang, Yi-Qun Zhong, Yun-Shi Zhou, Ping-Hong
Source	Medline; PMC
abstract	The main cause of death in colorectal carcinoma (CRC) patients is tumor metastasis; however, the underlying molecular mechanisms are largely unknown. In the present study, a novel metastasis-related gene, fibrinogen-like protein 2 (FGL2), was characterized for its role in CRC metastasis and underlying molecular mechanisms. The clinical significance of FGL2 was investigated using tissue microarray analysis of samples from 82 patients with CRC. The molecular effects of FGL2 in CRC cells were determined using RNA interference and ectopic expression of FGL2. The overexpression of FGL2 was examined by immunohistochemistry in 82 CRC patients, and it was determined to be an independent predictor of overall survival (P < 0.05). The depletion of FGL2 expression inhibited tumor progression and epithelial-to-mesenchymal transition (EMT) in vitro and in vivo, while ectopic overexpression of FGL2 enhanced cell invasion and induced EMT in vitro. Our results suggest that FGL2 plays an important oncogenic role in CRC aggressiveness by inducing EMT, and FGL2 could be employed as a novel prognostic marker and effective therapeutic target for CRC.
has issue date	2014-08-17(xsd:dateTime)
bibo:doi	10.1007/s12032-014-0181-7
bibo:pmid	25129313
has license	no-cc
sha1sum (hex)	bc4d62b08a22fd16f454479c41132f04481e167b
schema:url	https://doi.org/10.1007/s12032-014-0181-7
resource representing a document's title	Overexpression of fibrinogen-like protein 2 induces epithelial-to-mesenchymal transition and promotes tumor progression in colorectal carcinoma
has PubMed Central identifier	PMC7090555
has PubMed identifier	25129313
schema:publication	Med Oncol
resource representing a document's body	covid:bc4d62b08a22fd16f454479c41132f04481e167b#body_text
is schema:about of	named entity 'clinical' named entity 'Overexpression' named entity 'MESENCHYMAL' named entity 'CAUSE OF DEATH' named entity 'CRC' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'TUMOR METASTASIS' named entity 'CHARACTERIZED' named entity 'PRESENT' named entity 'CLINICAL SIGNIFICANCE' named entity 'INVESTIGATED' named entity 'FIBRINOGEN-LIKE PROTEIN 2' named entity 'OVERALL SURVIVAL' named entity 'STUDY' named entity 'DEPLETION' named entity 'OUR' named entity 'COLORECTAL CARCINOMA' named entity 'USING' named entity 'CELLS' named entity 'CELL INVASION' named entity 'THERAPEUTIC TARGET' named entity 'EFFECTIVE' named entity 'RNA INTERFERENCE' named entity 'OVEREXPRESSION' named entity 'ECTOPIC' named entity 'METASTASIS' named entity 'MAIN' named entity 'MOLECULAR' named entity 'AGGRESSIVENESS' named entity 'IN VIVO' named entity 'FGL2' named entity 'EMPLOYED' named entity 'ENHANCED' named entity 'IN VITRO' named entity 'OVEREXPRESSION' named entity 'EPITHELIAL' named entity 'FIBRINOGEN-LIKE PROTEIN 2' named entity 'INHIBITED' named entity 'PATIENTS' named entity 'PROGNOSTIC MARKER' named entity 'TISSUE MICROARRAY' named entity '0.05' named entity 'TRANSITION' named entity 'TUMOR PROGRESSION' named entity 'GENE' named entity 'DETERMINED' named entity 'INDEPENDENT' named entity 'COLORECTAL CARCINOMA' named entity 'TUMOR PROGRESSION' named entity 'INDUCING' named entity 'EXPRESSION' named entity 'INDUCED' named entity 'COULD BE' named entity 'LARGELY' named entity 'EMT' named entity 'EPITHELIAL-TO-MESENCHYMAL TRANSITION' named entity 'RELATED' named entity 'PREDICTOR' named entity 'MECHANISMS' named entity 'ECTOPIC EXPRESSION' named entity 'MICROARRAY ANALYSIS' named entity 'NOVEL' named entity 'PLAYS' named entity 'SAMPLES' named entity 'RESULTS' named entity 'EXAMINED' named entity 'ROLE' named entity 'UNDERLYING'

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