About: Identifying Major Histocompatibility Complex Supertypes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identifying Major Histocompatibility Complex Supertypes
Creator	Doytchinova^, Irini Flower^, Darren Guan^, Pingping
topic	covid:bc564d081e2ae9760838bb34534f126ae3479a79#this
Source	PMC
abstract	Human leukocyte antigen (HLA) recognizes antigenic fragments and presents them to T cells. HLA is polymorphic. There are over 2000 different HLA alleles at present and the number is constantly increasing. However, antigen binding studies are limited to a small proportion of these alleles; the binding specificities of most alleles are unknown. Several research groups have attempted to partition different HLA alleles into groups. In this chapter previous classifications are reviewed and we present two chemometric approaches to classifying class I HLA alleles. The program GRID is used to calculate interaction energy between protein molecules and defined chemical probes. These interaction energy values are imported into another program GOLPE and used for principal component analysis (PCA) calculation, which groups HLA alleles into supertypes. Amino acids that are involved in the classification are displayed in the loading plots of the PCA model. Another method, hierarchical clustering based on comparative molecular similarity indices (CoMSIA) is also applied to classify HLA alleles and the results are compared with those of the PCA models.
has issue date	2007-01-01(xsd:dateTime)
bibo:doi	10.1007/978-0-387-39241-7_11
has license	no-cc
sha1sum (hex)	bc564d081e2ae9760838bb34534f126ae3479a79
schema:url	https://doi.org/10.1007/978-0-387-39241-7_11
resource representing a document's title	Identifying Major Histocompatibility Complex Supertypes
has PubMed Central identifier	PMC7121619
schema:publication	In Silico Immunology
resource representing a document's body	covid:bc564d081e2ae9760838bb34534f126ae3479a79#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/bc564d081e2ae9760838bb34534f126ae3479a79
is schema:about of	named entity 'BASED' named entity 'CONSTANTLY' named entity 'CLASSIFYING' named entity 'RESULTS' named entity 'HLA' named entity 'HLA-B' named entity 'alleles' named entity 'alleles' named entity 'DPB1' named entity 'phylogenetic trees' named entity 'Thr' named entity 'HLA-C' named entity 'alleles' named entity 'hierarchical clustering' named entity 'protein sequence' named entity 'peptide' named entity 'HLA-B' named entity 'alleles' named entity 'peptide' named entity 'alleles' named entity 'epitopes' named entity 'superfamily' named entity 'allele' named entity 'alleles' named entity 'peptides' named entity 'A24' named entity 'polymorphic' named entity 'protein sequences' named entity 'HLA' named entity 'HLA-A' named entity 'HLA' named entity 'DRB3' named entity 'MHC' named entity 'hepatitis B virus' named entity 'alleles' named entity 'DQ3' named entity 'multiple alleles' named entity 'HLA' named entity 'beta chain' named entity 'B27' named entity 'superfamily' named entity 'vaccines' named entity 'B1501' named entity 'DQB1' named entity 'A01' named entity 'MHC' named entity 'hierarchical clustering' named entity 'K-means clustering' named entity 'NK cell' named entity 'HLA-A' named entity 'peptides' named entity 'epitope' named entity 'A*4301' named entity 'CPCA' named entity 'binding motifs' named entity 'alleles' named entity 'binding affinity' named entity 'amino acids' named entity 'HLA-A' named entity 'B27' named entity 'MHC' named entity 'A24' named entity 'HLA-C' named entity 'DRB1' named entity 'epitopes' named entity 'Epstein-Barr' named entity 'nucleated cells' named entity 'Alleles' named entity 'binding site' named entity 'ImMunoGeneTics' named entity 'A24' named entity 'immunologists' named entity 'HLA-A' named entity 'HLA-C' named entity 'HLA' named entity 'binding pockets' named entity 'MHC' named entity 'A23' named entity 'B27'

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