About: Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families
Creator	Lutz, Hans Hofmann-Lehmann, Regina Riond, Barbara Meli, Marina Cattori, Valentino Engels, Monika Franchini, Marco Robert-Tissot, Céline Moore, Peter Rüegger, Vera
source	Medline; PMC
abstract	Domestic cats are commonly affected by viral pathogens that induce lengthy infections with fatal outcomes. Prevention of viral propagation is of primordial importance in shelters and catteries, where cats from different backgrounds have narrow contacts. Oligonucleotides (ODN) containing cytosine-phosphate-guanosine motifs of class A (CpG-A) are highly potent synthetic inducers of innate antiviral mechanisms. The aim of this study was to test their ability to modulate innate immune responses and prevent viral replication as stand-alone agents in the domestic cat. CpG-A stimulation of feline peripheral blood mononuclear cells (PBMCs) enhanced their proliferation, increased the presence of co-stimulatory molecules on their surface and influenced their gene expression profiles in an antiviral orientation. Incubation of the supernatants of CpG-A stimulated PBMCs with feline cell lines of epithelial and fibroblastic origin induced expression of the antiviral myxovirus resistance (Mx) gene in these target cells, which also showed enhanced resistance to feline viruses from five distinct families, namely Coronaviridae, Herpesviridae, Caliciviridae, Parvoviridae, and Retroviridae. Most importantly, subcutaneous administration of CpG-A in domestic cats systemically increased the expression of Mx, reaching maximal levels within 24 h. Plasma from treated cats could furthermore inhibit viral replication in vitro. Altogether, our data highlight the promising potential of CpG-A to induce a preventive antiviral state in the cat and to protect feline populations against a broad range of virus infections.
has issue date	2012-08-20(xsd:dateTime)
bibo:doi	10.1186/1297-9716-43-60
bibo:pmid	22906110
has license	cc-by
sha1sum (hex)	bc5761e9d769b9fb1e723e1932ee3c5d4e21bd0a
schema:url	https://doi.org/10.1186/1297-9716-43-60
resource representing a document's title	Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families
has PubMed Central identifier	PMC3537549
has PubMed identifier	22906110
schema:publication	Vet Res
resource representing a document's body	covid:bc5761e9d769b9fb1e723e1932ee3c5d4e21bd0a#body_text
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