About: Respiratory syncytial virus entry and how to block it

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory syncytial virus entry and how to block it
Creator	Battles, Michael Mclellan, Jason
Source	Medline; PMC
abstract	Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an effective RSV vaccine has not been developed, and the only licensed intervention is passive immunoprophylaxis of high-risk infants with a humanized monoclonal antibody. During the past 5 years, however, there has been substantial progress in our understanding of the structure and function of the RSV glycoproteins and their interactions with host cell factors that mediate entry. This period has coincided with renewed interest in developing effective interventions, including the isolation of potent monoclonal antibodies and small molecules and the design of novel vaccine candidates. In this Review, we summarize the recent findings that have begun to elucidate RSV entry mechanisms, describe progress on the development of new interventions and conclude with a perspective on gaps in our knowledge that require further investigation.
has issue date	2019-02-05(xsd:dateTime)
bibo:doi	10.1038/s41579-019-0149-x
bibo:pmid	30723301
has license	no-cc
sha1sum (hex)	bc5ea849d39e9fd6e298e785868afbd481e8648d
schema:url	https://doi.org/10.1038/s41579-019-0149-x
resource representing a document's title	Respiratory syncytial virus entry and how to block it
has PubMed Central identifier	PMC7096974
has PubMed identifier	30723301
schema:publication	Nat Rev Microbiol
resource representing a document's body	covid:bc5ea849d39e9fd6e298e785868afbd481e8648d#body_text
is schema:about of	named entity 'FORMALIN' named entity 'substantial' named entity 'leading' named entity 'effective' named entity 'vaccine' named entity 'CAUSE' named entity 'VIRUS' named entity 'HOST CELL' named entity 'ENTRY' named entity 'IMMUNOPROPHYLAXIS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'PROGRESS' named entity 'PAST' named entity 'YEARS' named entity 'LEADING' named entity 'GAPS' named entity 'BLOCK' named entity 'HUMANIZED MONOCLONAL ANTIBODY' named entity 'RSV VACCINE' named entity 'RSV' named entity 'HIGH-RISK' named entity 'HAVE' named entity 'INVESTIGATION' named entity 'IS A' named entity 'GLYCOPROTEINS' named entity 'NOVEL' named entity 'VIRUS ENTRY' named entity 'HOW' named entity 'DESIGN' named entity 'PERSPECTIVE' named entity 'INTEREST' named entity 'NEW' named entity 'INFANTS' named entity 'ISOLATED' named entity 'STRUCTURE' named entity 'FUNCTION' named entity 'INTERVENTIONS' named entity 'PASSIVE' named entity 'OUR' named entity 'DEVELOPMENT' named entity 'INCLUDING' named entity 'THEIR' named entity 'INTERVENTION' named entity 'CONCLUDE' named entity 'MONOCLONAL ANTIBODIES' named entity 'LICENSED' named entity 'VACCINE' named entity 'PERIOD' named entity 'REVIEW' named entity 'ISOLATION' named entity 'MEDIATE' named entity 'FINDINGS' named entity 'UNDERSTANDING' named entity 'SMALL MOLECULES' named entity 'RECENT' named entity 'EFFECTIVE INTERVENTIONS' named entity 'YOUNG CHILDREN' named entity 'LOWER RESPIRATORY TRACT DISEASE' named entity 'EFFECTIVE' named entity 'MECHANISMS' named entity 'DEVELOPING' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'INTERACTIONS' named entity 'KNOWLEDGE' named entity 'DESCRIBE' named entity 'ELDERLY PEOPLE' named entity 'infants' named entity 'RSV' named entity 'monoclonal antibodies' named entity 'mediate' named entity 'respiratory tract' named entity 'RSV' named entity 'elderly' named entity 'small molecules' named entity 'host cell' named entity 'elderly people' named entity 'lower respiratory tract' named entity 'endocytic' named entity 'spatiotemporal regulation' named entity 'Paramyxoviridae'

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