About: Risk factors for disease progression in mild to moderate COVID-19 patients

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About: Risk factors for disease progression in mild to moderate COVID-19 patients– a multi-center observational study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors for disease progression in mild to moderate COVID-19 patients– a multi-center observational study
Creator	Zhu, Jie Shen, Ye Chen, Yang Shen, Chen Lei, Yu Xu, Cheng Zhang, Y Zhang, Zhu Cen, Yuan Chen, Xian Jiang, Wen-Rui Liu, Yu-Hui Xu, Hai-Tao Zhang, Li-Li Zhang, Xiao-Hua Liu, L-L
Source	Elsevier; Medline; PMC
abstract	OBJECTIVES: Since December 2019, patients infected with a novel coronavirus disease (COVID-19) emerged in Wuhan city and rapidly spread globally. The risk for poor outcome dramatically increases once a patient progressed to the severe or critical stage. The present study aims to investigate the risk factors for disease progression in mild to moderate cases of COVID-19. METHODS: We conducted a cohort study which included 1007 mild to moderate cases with COVID-19 from 3 hospitals in Wuhan. Clinical characteristics and baseline laboratory findings were collected. Patients had been followed up for 28 days for observation of disease progression. The endpoint was the progression to a more severe disease stage. RESULTS: During a follow up of 28 days, 720 patients (71.50%) had recovered or been symptomatically stable, 222 patients (22.05%) had progressed to the severe stage, 22 patients (2.18%) had progressed to the critically ill stage, 43 patients (4.27%) had deceased. Multivariate Cox proportional hazards models identified that increased age (HR 2.56, 95% CI 1.97 to 3.33), male sex (HR 1.79, 95% CI 1.41 to 2.28), presence of hypertension (HR 1.44, 95% CI 1.11 to 1.88), diabetes (HR 1.82, 95% CI 1.35 to 2.44), chronic obstructive pulmonary disease (HR 2.01, 95% CI 1.38 to 2.93) and coronary artery disease (HR 1.83, 95% CI 1.26 to 2.66) were risk factors for disease progression. History of smoking was protective against disease progression (HR 0.56, 95% CI 0.34 to 0.91). Elevated procalcitonin (HR 1.72, 95% CI 1.02 to 2.90), urea nitrogen (HR 1.72, 95% CI 1.21 to 2.43), α-hydroxybutyrate dehydrogenase (HR 3.02, 95% CI 1.26 to 7.21) and D-dimer (HR 2.01, 95% CI 1.12 to 3.58) at baseline were also associated with risk for disease progression. CONCLUSIONS: This study identified a panel of risk factors for disease progression in mild to moderate cases with COVID-19.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1016/j.cmi.2020.05.041
bibo:pmid	32526275
has license	no-cc
sha1sum (hex)	bc64689257dff3124c92226bd68bac3380c065f0
schema:url	https://doi.org/10.1016/j.cmi.2020.05.041
resource representing a document's title	Risk factors for disease progression in mild to moderate COVID-19 patients– a multi-center observational study
has PubMed Central identifier	PMC7280135
has PubMed identifier	32526275
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:bc64689257dff3124c92226bd68bac3380c065f0#body_text
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