About: When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses

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About: When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses
Creator	Izquierdo-Useros, Nuria Martinez-Picado, Javier Perez-Zsolt, Daniel
Source	PMC
abstract	Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen presenting cells (APCs) prime specific adaptive immune responses. Some viruses, however, have evolved strategies to subvert the migratory capacity of DCs as a way to disseminate infection systemically. Here we focus on the role of Siglec-1, a sialic acid-binding type I lectin receptor potently upregulated by type I interferons on DCs, that acts as a double edge sword, containing viral replication through the induction of antiviral immunity, but also favoring viral spread within tissues. Such is the case for distant enveloped viruses like human immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic acid-containing gangliosides on their viral membrane and are effectively recognized by Siglec-1. Here we review how Siglec-1 is highly induced on the surface of human DCs upon viral infection, the way this impacts different antigen presentation pathways, and how enveloped viruses have evolved to exploit these APC functions as a potent dissemination strategy in different anatomical compartments.
has issue date	2019-12-19(xsd:dateTime)
bibo:doi	10.3390/v12010008
bibo:pmid	31861617
has license	cc-by
sha1sum (hex)	bc763a4c1cb0175d61d1332af8d137d0482df73b
schema:url	https://doi.org/10.3390/v12010008
resource representing a document's title	When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses
has PubMed Central identifier	PMC7019426
has PubMed identifier	31861617
schema:publication	Viruses
resource representing a document's body	covid:bc763a4c1cb0175d61d1332af8d137d0482df73b#body_text
is schema:about of	named entity 'adaptive immune responses' named entity 'exploit' named entity 'Some' named entity 'focus' named entity 'migratory' named entity 'recognized' named entity 'upregulated' named entity 'receptor' named entity 'potent' named entity 'tissues' named entity 'anatomical' named entity 'effectively' named entity 'tissues' named entity 'evolved' named entity 'recognize' named entity 'Initial' named entity 'APC' named entity 'upregulated' named entity 'DCs' named entity 'APCs' named entity 'virus' named entity 'DCs' named entity 'Siglec' named entity 'enveloped viruses' named entity 'secondary lymphoid tissues' named entity 'DCs' named entity 'EBOV' named entity 'Siglec' named entity 'Toll-like receptor' named entity 'DCs' named entity 'MHC-II' named entity 'mucosa' named entity 'IFNα' named entity 'SAMHD1' named entity 'DCs' named entity 'monocytes' named entity 'Siglec' named entity 'monocyte' named entity 'lectin' named entity 'IFNα' named entity 'DCs' named entity 'infectious agents' named entity 'antigen presentation' named entity 'Siglec' named entity 'cross-presentation' named entity 'type I interferons' named entity 'APC' named entity 'DCs' named entity 'CLRs' named entity 'viral antigens' named entity 'cytokine' named entity 'type I IFNs' named entity 'cytokine' named entity 'EBOV' named entity 'viruses' named entity 'viral infections' named entity 'IFNα' named entity '1, 2' named entity 'Siglec' named entity 'HIV-1' named entity 'secretion' named entity 'macrophages' named entity 'lymph node' named entity 'extracellular vesicles' named entity 'cellular membrane' named entity 'antiviral' named entity 'DCs' named entity 'EBOV' named entity 'CD4 +' named entity 'Siglec' named entity 'Siglec' named entity 'myeloid' named entity 'epithelial barrier' named entity 'bone marrow' named entity 'DCs' named entity 'EBOV' named entity 'antigen' named entity 'HIV-1' named entity 'cell cytoplasm'

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