About: In-depth characterization of a novel live-attenuated Mayaro virus vaccine candidate using an immunocompetent mouse model of Mayaro disease

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About: In-depth characterization of a novel live-attenuated Mayaro virus vaccine candidate using an immunocompetent mouse model of Mayaro disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In-depth characterization of a novel live-attenuated Mayaro virus vaccine candidate using an immunocompetent mouse model of Mayaro disease
Creator	Weaver, Scott Martins Teixeira, Mauro Fulgêncio Queiroz, Victoria Hubner, Josy Santos, Franciele Souza, Danielle Sugimoto, Michelle Daiane De Sousa, Carla De Freitas Guimarães, Georgia Lacerda Nogueira, Maurício Martins Queiroz-Junior, Celso Pinto Moreira, Thaiane Tasso De Oliveira Mota, Mânlio Vasconcelos Costa, Vivian
Source	PMC
abstract	Mayaro virus (MAYV) is endemic in South American countries where it is responsible for sporadic outbreaks of acute febrile illness. The hallmark of MAYV infection is a highly debilitating and chronic arthralgia. Although MAYV emergence is a potential threat, there are no specific therapies or licensed vaccine. In this study, we developed a murine model of MAYV infection that emulates many of the most relevant clinical features of the infection in humans and tested a live-attenuated MAYV vaccine candidate (MAYV/IRES). Intraplantar inoculation of a WT strain of MAYV into immunocompetent mice induced persistent hypernociception, transient viral replication in target organs, systemic production of inflammatory cytokines, chemokines and specific humoral IgM and IgG responses. Inoculation of MAYV/IRES in BALB/c mice induced strong specific cellular and humoral responses. Moreover, MAYV/IRES vaccination of immunocompetent and interferon receptor-defective mice resulted in protection from disease induced by the virulent wt MAYV strain. Thus, this study describes a novel model of MAYV infection in immunocompetent mice and highlights the potential role of a live-attenuated MAYV vaccine candidate in host’s protection from disease induced by a virulent MAYV strain.
has issue date	2020-03-24(xsd:dateTime)
bibo:doi	10.1038/s41598-020-62084-x
bibo:pmid	32210270
has license	cc-by
sha1sum (hex)	bca052bc8803da1be4388a5f7466b0005dff7893
schema:url	https://doi.org/10.1038/s41598-020-62084-x
resource representing a document's title	In-depth characterization of a novel live-attenuated Mayaro virus vaccine candidate using an immunocompetent mouse model of Mayaro disease
has PubMed Central identifier	PMC7093544
has PubMed identifier	32210270
schema:publication	Sci Rep
resource representing a document's body	covid:bca052bc8803da1be4388a5f7466b0005dff7893#body_text
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