About: In Ovo Delivered Toll-Like Receptor 7 Ligand, Resiquimod Enhances Host Responses against Infectious Bronchitis Corona Virus (IBV) Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In Ovo Delivered Toll-Like Receptor 7 Ligand, Resiquimod Enhances Host Responses against Infectious Bronchitis Corona Virus (IBV) Infection
Creator	Amarasinghe, Aruna Czub, Markus De, Upasama Faizal Abdul-Careem, Mohamed Senapathi, Silva Van Marle, Guido Aboelkhair, Mohamed Ali, Mariam Puro, Kekungu Sarjoon Abdul-Cader, M
Source	Medline; PMC
abstract	Toll-like receptor (TLR) 7 ligand, resiquimod, has been studied as an adjuvant and antiviral agent against several pathogens in chicken. Yet, the effectiveness of resiquimod against infectious bronchitis virus (IBV) infection has not been evaluated. In this study, we investigated the effectiveness of resiquimod delivered pre-hatch (in ovo) against IBV infection post-hatch identifying key mechanisms involved in resiquimod driven immune activation. First, we found an upregulation of interleukin (IL)-1β and interferon (IFN)-γ mRNA levels and considerable expansions of macrophage and cluster of differentiation (CD) 8α+ T cell populations in lungs of chicken as early as day one post-hatch, following pre-hatch delivery of resiquimod. Second, we observed that resiquimod was able to act as an adjuvant when resiquimod was delivered pre-hatch along with an inactivated IBV vaccine. Finally, when the resiquimod pretreated one-day-old chickens were infected with IBV, reduction in viral shedding via oral and fecal routes was observed at 3 days post- infection. Overall, this study shows that the pre-hatch delivered resiquimod increases cell-mediated immune responses in lungs with an advantage of reduction in IBV shedding.
has issue date	2020-04-15(xsd:dateTime)
bibo:doi	10.3390/vaccines8020186
bibo:pmid	32326430
has license	cc-by
sha1sum (hex)	bca3dcfd6a91d44c61c3bf5f3e0e50881380c75c
schema:url	https://doi.org/10.3390/vaccines8020186
resource representing a document's title	In Ovo Delivered Toll-Like Receptor 7 Ligand, Resiquimod Enhances Host Responses against Infectious Bronchitis Corona Virus (IBV) Infection
has PubMed Central identifier	PMC7349678
has PubMed identifier	32326430
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:bca3dcfd6a91d44c61c3bf5f3e0e50881380c75c#body_text
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