About: Protein Chip Array Profiling Analysis in Patients with Severe Acute Respiratory Syndrome Identified Serum Amyloid A Protein as a Biomarker Potentially Useful in Monitoring the Extent of Pneumonia

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About: Protein Chip Array Profiling Analysis in Patients with Severe Acute Respiratory Syndrome Identified Serum Amyloid A Protein as a Biomarker Potentially Useful in Monitoring the Extent of Pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protein Chip Array Profiling Analysis in Patients with Severe Acute Respiratory Syndrome Identified Serum Amyloid A Protein as a Biomarker Potentially Useful in Monitoring the Extent of Pneumonia
Creator	Wang, Zheng Lim, Wilina Yip, Tai-Tung Chan, John Chan, Johnny Law, Stephen Ngan, Roger Yip, Timothy Au, Joseph Chan, Angel Cheng, Wai-Wai Cho, C Kwan, Ting-Lok Lee, King-Chung Lim, Cadmon Ma, Victor Tsang, Dominic William, † Yip, Christine
Source	Medline; PMC
abstract	Background: A new strain of coronavirus (CoV) has caused an outbreak of severe acute respiratory syndrome (SARS), with 8098 individuals being infected and 774 deaths worldwide. We carried out protein chip array profiling analysis in an attempt to identify biomarkers that might be useful in monitoring the clinical course of SARS patients. Methods: We performed surface-enhanced laser desorption ionization time-of-flight mass spectrometry on 89 sera collected from 28 SARS patients, 72 sera from 51 control patients with various viral or bacterial infections, and 10 sera from apparently healthy individuals. Results: Nine significantly increased and three significantly decreased serum biomarkers were discovered in the SARS patients compared with the controls. Among these biomarkers, one (11 695 Da) was identified to be serum amyloid A (SAA) protein by peptide mapping and tandem mass spectrometric analysis. When we monitored the SAA concentrations longitudinally in 45 sera from four SARS patients, we found a good correlation of SAA concentration with the extent of pneumonia as assessed by a serial chest x-ray opacity score. Increased SAA occurred in three of four patients at the time of extensive pneumonia as indicated by high x-ray scores. Over the course of gradual recovery in two patients, as assessed clinically and radiologically, SAA concentrations gradually decreased. In the third patient, the concentrations were initially increased, but were further increased with superimposed multiple bacterial infections. SAA was not markedly increased in the fourth patient, who had low x-ray scores and whose clinical course was relatively mild. Conclusions: Protein chip array profiling analysis could be potentially useful in monitoring the severity of disease in SARS patients.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1373/clinchem.2004.031229
bibo:pmid	15364884
has license	no-cc
sha1sum (hex)	bcbfcabedc85544a2fc81bd00dc95fb752cb6e0d
schema:url	https://doi.org/10.1373/clinchem.2004.031229
resource representing a document's title	Protein Chip Array Profiling Analysis in Patients with Severe Acute Respiratory Syndrome Identified Serum Amyloid A Protein as a Biomarker Potentially Useful in Monitoring the Extent of Pneumonia
has PubMed Central identifier	PMC7108187
has PubMed identifier	15364884
schema:publication	Clin Chem
resource representing a document's body	covid:bcbfcabedc85544a2fc81bd00dc95fb752cb6e0d#body_text
is schema:about of	named entity 'time' named entity 'peptide mapping' named entity 'bacterial infections' named entity 'individuals' named entity 'serial' named entity 'profiling' named entity 'chip' named entity 'fourth' named entity 'Profiling' named entity 'IDENTIFIED' named entity 'SERUM AMYLOID A' named entity 'HEALTHY' named entity 'SERIAL' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'RESULTS' named entity 'THESE' named entity 'MIGHT BE' named entity 'SERUM BIOMARKERS' named entity 'MARKEDLY' named entity 'DEATHS' named entity 'OPACITY' named entity 'INCREASED' named entity 'BACTERIAL INFECTIONS' named entity 'COURSE' named entity 'SCORE' named entity 'INITIALLY' named entity 'BEING' named entity 'CORRELATION' named entity 'PATIENT' named entity 'IDENTIFIED' named entity 'CONTROL' named entity 'TIME' named entity 'TIME-OF-FLIGHT MASS SPECTROMETRY' named entity 'EXTENT OF' named entity 'DISEASE' named entity 'SERA' named entity 'WORLDWIDE' named entity 'MONITORING' named entity 'MILD' named entity 'BUT' named entity 'BIOMARKERS' named entity 'SAA' named entity 'ASSESSED' named entity 'GOOD' named entity 'CAUSED' named entity 'FOUND' named entity 'USEFUL' named entity 'INFECTED' named entity 'CHEST X-RAY' named entity 'SEVERITY' named entity 'USEFUL' named entity 'MONITORING' named entity 'PROTEIN ' named entity 'ENHANCED' named entity 'PROTEIN ' named entity 'PERFORMED' named entity 'INDICATED' named entity 'PATIENTS' named entity 'PEPTIDE MAPPING' named entity 'LASER DESORPTION IONIZATION' named entity 'CONCENTRATIONS' named entity 'CARRIED' named entity 'DECREASED'

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