About: SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology

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About: SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology
Creator	Commentaries, Perspective,
Source	Medline; PMC
abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on 11th March 2020. Bulk of research on this virus are carried out to unveil its multivariate pathology. Surprisingly, men are reportedly more vulnerable to COVID-19 even with higher fatality rate compared to women. Thus, it is crucial to determine whether SARS-CoV-2 infection can even affect male fertility as an immediate or long-term consequence of the disease. Among the discrete data available, an important finding is that angiotensin converting enzymes 2 (ACE2) receptor, that aids the SARS-CoV-2 entry into host cells, is profoundly expressed in testicular cells. In addition, the endogenous androgen milieu and its receptors are associated with ACE2 activation reflecting that enhanced testosterone levels may trigger the pathogenesis of COVID-19. In contrary, hypogonadism has also been reported in the acute phase of some COVID-19 cases. Moreover, SARS-CoV-2 infection-induced uncontrolled inflammatory responses may lead to systemic oxidative stress (OS), whose severe disruptive effects on testicular functions are well-documented. This article aims to precisely present the possible impact of COVID-19 on male reproductive functions, and to highlight the speculations that need in-depth research for the exact underlying mechanisms how COVID-19 is associated with men’s health and fertility.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1007/s43032-020-00261-z
bibo:pmid	32651900
has license	no-cc
sha1sum (hex)	bccf1c3bbe5fc0e9d08b6b8c16d2ae5f96491fb1
schema:url	https://doi.org/10.1007/s43032-020-00261-z
resource representing a document's title	SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology
has PubMed Central identifier	PMC7351544
has PubMed identifier	32651900
schema:publication	Reprod Sci
resource representing a document's body	covid:bccf1c3bbe5fc0e9d08b6b8c16d2ae5f96491fb1#body_text
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