About: Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease

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About: Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease
Creator	Lim, Hye-Sun Choi, Goya Jeon, Mijin Kim, Joong-Sun Lee, Jun Moon, Changjong Park, Gunhyuk Ryu, Seung Ang, Mary Moon, Byeong
Source	Medline; PMC
abstract	Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta (SNPC) and the striatum. Nuclear receptor-related 1 protein (Nurr1) is a nuclear hormone receptor implicated in limiting mitochondrial dysfunction, apoptosis, and inflammation in the central nervous system and protecting dopaminergic neurons and a promising therapeutic target for PD. Cicadidae Periostracum (CP), the cast-off skin of Cryptotympana pustulata Fabricius, has been used in traditional medicine for its many clinical pharmacological effects, including the treatment of psychological symptoms in PD. However, scientific evidence for the use of CP in neurodegenerative diseases, including PD, is lacking. Here, we investigated the protective effects of CP on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced PD in mice and explored the underlying mechanisms of action, focusing on Nurr1. CP increased the expression levels of Nurr1, tyrosine hydroxylase, DOPA decarboxylase, dopamine transporter, and vesicular monoamine transporter 2 via extracellular signal-regulated kinase phosphorylation in differentiated PC12 cells and the mouse SNPC. In MPTP-induced PD, CP promoted recovery from movement impairments. CP prevented dopamine depletion and protected against dopaminergic neuronal degradation via mitochondria-mediated apoptotic proteins such as B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X, cytochrome c, and cleaved caspase-9 and caspase-3 by inhibiting MPTP-induced neuroinflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase 2, and glial/microglial activation. Moreover, CP inhibited lipopolysaccharide-induced neuroinflammatory cytokines and response levels and glial/microglial activation in BV2 microglia and the mouse brain. Our findings suggest that CP might contribute to neuroprotective signaling by regulating neurotrophic factors primarily via Nurr1 signaling, neuroinflammation, and mitochondria-mediated apoptosis.
has issue date	2019-10-24(xsd:dateTime)
bibo:doi	10.1155/2019/5797512
bibo:pmid	31772707
has license	cc-by
sha1sum (hex)	bd6dd93085fa736cac9569090a8cb88324daf18f
schema:url	https://doi.org/10.1155/2019/5797512
resource representing a document's title	Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease
has PubMed Central identifier	PMC6854990
has PubMed identifier	31772707
schema:publication	Oxid Med Cell Longev
resource representing a document's body	covid:bd6dd93085fa736cac9569090a8cb88324daf18f#body_text
is schema:about of	named entity 'DOPAMINERGIC NEURONS' named entity 'focusing' named entity 'nitric oxide synthase' named entity 'dopaminergic' named entity 'methyl' named entity 'symptoms' named entity 'striatum' named entity 'scientific evidence' named entity 'Cicadidae' named entity 'Skin' named entity 'CLINICAL' named entity 'PARKINSON' named entity 'SUBSTANTIA NIGRA PARS COMPACTA' named entity 'CRYPTOTYMPANA PUSTULATA' named entity 'CYTOCHROME C' named entity 'ACTIVATION' named entity 'RECOVERY' named entity 'MICE' named entity 'LACKING' named entity 'PHOSPHORYLATION' named entity 'FINDINGS' named entity 'IMPAIRMENTS' named entity 'CHARACTERIZED' named entity 'STRIATUM' named entity 'USED' named entity 'CLEAVED CASPASE-9' named entity 'USE OF' named entity 'BV2' named entity 'PROTEIN ' named entity 'INVESTIGATED' named entity 'VESICULAR MONOAMINE TRANSPORTER 2' named entity 'TRADITIONAL MEDICINE' named entity 'NEUROPROTECTIVE' named entity 'NEUROINFLAMMATION' named entity 'DOPAMINE TRANSPORTER' named entity 'FOCUSING' named entity 'PHENYL' named entity 'RESPONSE' named entity 'EVIDENCE FOR' named entity 'REGULATING' named entity 'CYCLOOXYGENASE 2' named entity 'CICADIDAE' named entity 'DOPAMINERGIC' named entity 'MOVEMENT' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'NEURONAL LOSS IN THE SUBSTANTIA NIGRA' named entity 'IS A' named entity 'MEDIATED' named entity 'CASPASE-3' named entity 'RELATED' named entity 'MICROGLIA' named entity 'MITOCHONDRIA' named entity 'INHIBITING' named entity 'TREATMENT' named entity 'CAST' named entity 'DEPLETION' named entity 'OUR' named entity 'APOPTOTIC' named entity 'EFFECTS' named entity 'NURR1' named entity 'ASSOCIATED' named entity 'PHARMACOLOGICAL' named entity 'TYROSINE HYDROXYLASE' named entity 'EXPRESSION' named entity 'MOUSE' named entity '28PD' named entity 'SNPC' named entity 'CICADIDAE' named entity 'CICADA' named entity 'LEVELS' named entity 'CYTOKINES' named entity 'MPTP'

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