About: Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone

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About: Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone
Creator	Chan, C Zhang, G Leung, K Cheung, W Griffith, J Qin, L Sheng, H Yeung, H Yeung, K Chiu, K
Source	Elsevier; Medline; PMC
abstract	AIMS: The present study employed both static and dynamic imaging modalities to study both intra- and extravascular events attributing to steroid-associated osteonecrosis (ON) using an experimental protocol with a single low-dose lipopolysaccharide (LPS) injection and subsequently three injections of high-dose methylprednisolone (MPS). METHODS: Fourteen 28-week-old male New Zealand white rabbits received one intravenous injection of LPS (10 μg/kg). 24 h later, three injections of 20 mg/kg of MPS were given intramuscularly at a time interval of 24 h. Additional 6 rabbits were used as controls. Dynamic MRI was performed on bilateral femora for local intraosseous perfusion before and after LPS injection. Blood samples were collected for hematological examinations before and after LPS injection. Bilateral femora were dissected and decalcified for microCT-based microangiography. ON lesion, intravascular thrombus and extravascular marrow fat cell size were examined histopathologically. RESULTS: Intravascular thrombus was observed in all ON rabbits. Extravascular marrow fat cell size was significantly increased in ON rabbits than that of the controls (P < 0.05). Compared to baseline, a significant decrease in ratio of tissue-type plasminogen activator/plasminogen activator inhibitor 1, activated partial thromboplatin time and a significant increase in ratio of low-density lipoprotein/high-density lipoprotein were only found in ON rabbits (P < 0.05). Dynamic MRI showed a significant decrease in the perfusion index ‘maximum enhancement’ in the ON rabbits (P < 0.05), and microCT-based microangiography showed blocked stem vessels in ON samples. Overall, 93% of the rabbits (13/14) developed ON, and no rabbits died throughout the experiment period. CONCLUSION: Both intra- and extravascular events were found attributing to the steroid-associated ON based on our experimental protocol with a single low-dose LPS injection and subsequent three injections of high-dose MPS. Both high ON incidence and no mortality in rabbits treated with this inductive protocol suggested its effectiveness for future studies on evaluation of therapeutic efficacy of interventions developed for prevention of steroid-associated ON.
has issue date	2006-06-12(xsd:dateTime)
bibo:doi	10.1016/j.bone.2006.04.018
bibo:pmid	16765664
has license	no-cc
sha1sum (hex)	bd6f56839e4ab33f80a8cf0bbe48b410503a8cf4
schema:url	https://doi.org/10.1016/j.bone.2006.04.018
resource representing a document's title	Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone
has PubMed Central identifier	PMC7103395
has PubMed identifier	16765664
schema:publication	Bone
resource representing a document's body	covid:bd6f56839e4ab33f80a8cf0bbe48b410503a8cf4#body_text
is schema:about of	named entity 'Bilateral' named entity 'MPS' named entity 'perfusion' named entity 'static' named entity 'ratio' named entity 'intravenous injection' named entity 'therapeutic' named entity 'perfusion' named entity 'intraosseous' named entity 'observed' named entity 'injection' named entity 'BIOIMAGING' named entity 'COMBINATION' named entity 'MICROANGIOGRAPHY' named entity 'STATIC' named entity 'EXPERIMENT' named entity 'PROTOCOL' named entity 'LIPOPOLYSACCHARIDE' named entity 'EXPERIMENTAL' named entity 'DECREASE' named entity '28P' named entity 'PERIOD' named entity 'ENHANCEMENT' named entity 'INCIDENCE' named entity 'METHODS' named entity 'MICROCT' named entity 'STEROID' named entity 'EMPLOYED' named entity 'INTRAOSSEOUS' named entity 'EXAMINED' named entity 'EVALUATION' named entity 'BILATERAL' named entity 'STEM' named entity 'COMPARED' named entity 'STUDIES' named entity 'EXPERIMENTAL PROTOCOL' named entity 'HIGH' named entity 'ITS' named entity 'VESSELS' named entity 'BASED' named entity 'THROMBUS' named entity 'ASSOCIATED' named entity 'LATER' named entity 'DYNAMIC MRI' named entity 'STUDY' named entity '0.05' named entity 'ADDITIONAL' named entity 'LOCAL' named entity 'GIVEN' named entity 'BLOCKED' named entity 'SAMPLES' named entity 'RATIO' named entity 'OLD' named entity 'ACTIVATED' named entity 'WEEK' named entity 'HEMATOLOGICAL' named entity 'MG%' named entity 'DENSITY' named entity 'FUTURE' named entity 'INTRAVASCULAR' named entity 'BCG' named entity 'CONCLUSION' named entity 'FOURTEEN' named entity 'LIPOPROTEIN' named entity 'FAT CELL SIZE' named entity 'EFFECTIVENESS' named entity 'SUBSEQUENT' named entity 'AIMS' named entity 'INCREASED' named entity 'TIME INTERVAL' named entity 'OSTEONECROSIS' named entity 'INDUCED'

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