About: Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity

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About: Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity
Creator	Chow, Angela Lecuit, Marc Her, Zhisheng Leo, Yee-Sin Kam, Yiu-Wing Couderc, Thérèse Chia, Bing-Shao Lum, Fok-Moon Ong, Ruo-Yan Rénia, Laurent Ng, Lisa
Source	PMC
abstract	The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but antibodies present at sub-neutralizing concentrations can also augment virus infection that exacerbates disease severity. To explore this occurrence, CHIKV infection was investigated in the presence of CHIKV-specific antibodies in both primary human cells and a murine macrophage cell line, RAW264.7. Enhanced attachment of CHIKV to the primary human monocytes and B cells was observed while increased viral replication was detected in RAW264.7 cells. Blocking of specific Fc receptors (FcγRs) led to the abrogation of these observations. Furthermore, experimental infection in adult mice showed that animals had higher viral RNA loads and endured more severe joint inflammation in the presence of sub-neutralizing concentrations of CHIKV-specific antibodies. In addition, CHIKV infection in 11 days old mice under enhancing condition resulted in higher muscles viral RNA load detected and death. These observations provide the first evidence of antibody-mediated enhancement in CHIKV infection and pathogenesis and could also be relevant for other important arboviruses such as Zika virus.
has issue date	2018-01-30(xsd:dateTime)
bibo:doi	10.1038/s41598-018-20305-4
bibo:pmid	29382880
has license	cc-by
sha1sum (hex)	bda897976d2a119dd7f4505065d769c3b93cddf7
schema:url	https://doi.org/10.1038/s41598-018-20305-4
resource representing a document's title	Antibody-mediated enhancement aggravates chikungunya virus infection and disease severity
has PubMed Central identifier	PMC5789897
has PubMed identifier	29382880
schema:publication	Sci Rep
resource representing a document's body	covid:bda897976d2a119dd7f4505065d769c3b93cddf7#body_text
is schema:about of	named entity 'CHIKUNGUNYA VIRUS INFECTION' named entity 'RNA' named entity 'cell' named entity 'explore' named entity 'CHIKV' named entity 'B cells' named entity 'augment' covid:arg/bda897976d2a119dd7f4505065d769c3b93cddf7 named entity 'SPECIFIC' named entity 'HUMAN MONOCYTES' named entity 'VIRUS INFECTION' named entity 'OLD' named entity 'SEVERE' named entity 'CONDITION' named entity 'NEW' named entity 'HAVE' named entity 'ADULT' named entity 'RELEVANT' named entity 'DEATH' named entity 'RESEARCH' named entity 'TRANSMITTED' named entity 'HUMAN CELLS' named entity 'ARTHROPOD' named entity 'EXACERBATES' named entity 'B CELLS' named entity 'RAW264.7' named entity 'IMPORTANT' named entity 'DISEASE' named entity 'CHARACTERIZED' named entity 'OBSERVATIONS' named entity 'INCREASED' named entity 'VIRAL REPLICATION' named entity 'ANTIBODIES' named entity 'SUB-' named entity 'OCCURRENCE' named entity 'ATTACHMENT' named entity 'BLOCKING' named entity 'CAUSES' named entity 'MACROPHAGE CELL LINE' named entity 'MURINE' named entity 'BUT' named entity 'CONTINUAL' named entity 'PROVIDE' named entity 'MEDIATED' named entity 'JOINT INFLAMMATION' named entity 'CHIKUNGUNYA VIRUS' named entity 'TO CONTROL' named entity 'EXPERIMENTAL INFECTION' named entity 'FLU' named entity 'MUSCLES' named entity 'DISEASE SEVERITY' named entity 'MICE' named entity 'ANTIBODY' named entity 'AGGRAVATES' named entity 'MEDIATED' named entity 'ENHANCEMENT' named entity 'LIKE' named entity 'RISK OF' named entity 'DETECTED' named entity 'FC RECEPTORS' named entity 'LED' named entity 'LOAD' named entity 'ENHANCED' named entity 'PATHOGENESIS' named entity 'ANTIBODY' named entity 'EMERGENCE' named entity 'CHIKV INFECTION' named entity 'ANIMALS' named entity 'DISEASE SEVERITY' named entity 'HIGHER' named entity 'VIRUS'

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