About: Association of Human-Leukocyte-Antigen Class I (B*0703) and Class II (DRB1*0301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome

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About: Association of Human-Leukocyte-Antigen Class I (B0703) and Class II (DRB10301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Association of Human-Leukocyte-Antigen Class I (B0703) and Class II (DRB10301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome
Creator	Leung, Chi-Bon Sung, Joseph Zee, Benny Ng, Margaret Chan, Wing Cheng, Suk-Hang Hui, Pak Lau, Kin-Mang Li, Libby
source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B0703 (OR, 4.08; 95% CI, 2.03–8.18; P = .00072 [Bonferroni-corrected P value, P(c)<.0022]) and -DRB10301 (OR, 0.06; 95%, 0.01–0.47; P = .00008 [after Bonferroni correction, P<.0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%–19.0%) in our SARS group was significantly higher (P = 3×10(−9)) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.
has issue date	2004-08-01(xsd:dateTime)
bibo:doi	10.1086/421523
bibo:pmid	15243926
has license	no-cc
sha1sum (hex)	bdde12397b23a71a93e121e5906bdfd2a01b46ef
schema:url	https://doi.org/10.1086/421523
resource representing a document's title	Association of Human-Leukocyte-Antigen Class I (B0703) and Class II (DRB10301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome
has PubMed Central identifier	PMC7109646
has PubMed identifier	15243926
schema:publication	J Infect Dis
resource representing a document's body	covid:bdde12397b23a71a93e121e5906bdfd2a01b46ef#body_text
is schema:about of	named entity 'DEVELOPMENT' named entity 'HUMAN-LEUKOCYTE' named entity 'Antigen' named entity 'IS A' named entity 'WORLDWIDE' named entity 'SARS' named entity 'INFECTIONS' named entity 'ASSOCIATION' named entity 'CONCERN' named entity 'IDENTIFIED' named entity 'CONFIRMED' named entity 'RESISTANCE TO' named entity 'CHINESE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ANTIGEN' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'TYPES' covid:arg/bdde12397b23a71a93e121e5906bdfd2a01b46ef named entity 'HUMAN LEUKOCYTE ANTIGEN' named entity 'CLASS I' named entity 'SUSCEPTIBILITY' named entity 'ASSOCIATION' named entity 'GENOTYPES' named entity 'HLA-B' named entity 'PATIENTS' named entity 'ALLELES' named entity 'STRONG' named entity 'PUBLIC HEALTH' named entity 'CLASS II' named entity 'alleles' named entity 'types' named entity 'confirmed' named entity 'Severe Acute Respiratory Syndrome' named entity 'HLA' named entity 'SARS' named entity 'Severe acute respiratory syndrome' named entity 'Antigen' named entity 'infectious disease' named entity 'infection' named entity 'human leukocyte antigen' named entity 'locus' named entity 'DRB1' named entity 'SARS' named entity 'Fisher's exact test' named entity 'odds ratio' named entity 'HLA-B' named entity 'DNA-based' named entity 'SARS' named entity 'intensive care units' named entity 'class II' named entity 'HCV' named entity 'HLA-B' named entity 'helper cells' named entity 'chloroform' named entity 'HLA' named entity '1, 2' named entity 'SARS' named entity 'lung' named entity 'pathogenesis' named entity 'Hong Kong' named entity 'HLA-B' named entity 'SARS' named entity 'DQB1' named entity 'phenol' named entity 'Bonferroni correction' named entity 'antiviral' named entity 'vaccination' named entity 'control population' named entity 'linked genes' named entity '95% CI' named entity 'WHO' named entity 'public health' named entity 'DQB1'

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About: Association of Human-Leukocyte-Antigen Class I (B*0703) and Class II (DRB1*0301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome Goto Sponge NotDistinct Permalink

About: Association of Human-Leukocyte-Antigen Class I (B0703) and Class II (DRB10301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome Goto Sponge NotDistinct Permalink