About: The clinical and immunological features of pediatric COVID-19 patients in China

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The clinical and immunological features of pediatric COVID-19 patients in China
Creator	Chen, Yao-Kai Xu, Hong-Mei Hu, Yuan Chen, Juan Li, Zhi-Jie Tian, Wen-Guang Cai, Xue-Fei Deng, Hai-Jun Hu, Jie-Li Hu, Peng Huang, Ai-Long Liao, Pu Liu, Bei-Zhong Long, Quan-Xin Tang, Ni Wang, De-Qiang Wu, Gui-Cheng Xiang, Jiang-Lin Zhang, Xian-Xiang Wang, Dao-Xin Zhou, Fa-Chun Zhang, Zhen-Zhen
Source	Elsevier; Medline; PMC
abstract	In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3–4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1016/j.gendis.2020.03.008
bibo:pmid	32363222
has license	no-cc
sha1sum (hex)	bdf804c3d67e837df076ec2d5ae99c9f27d8bc0d
schema:url	https://doi.org/10.1016/j.gendis.2020.03.008
resource representing a document's title	The clinical and immunological features of pediatric COVID-19 patients in China
has PubMed Central identifier	PMC7194810
has PubMed identifier	32363222
schema:publication	Genes Dis
resource representing a document's body	covid:bdf804c3d67e837df076ec2d5ae99c9f27d8bc0d#body_text
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