About: Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection

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About: Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection
Creator	Kim, Yeo Chul, Myung Kim, Jung-Eun
source	Medline; PMC
abstract	OBJECTIVES: We investigated serum cytokine levels in pediatric patients with pandemic influenza H1N1 2009 virus (H1N1) infection‐pneumonia and in pediatric patients with pneumonia but without H1N1 infection, and examined correlations between cytokine levels and clinical/laboratory findings. METHODS: Fifty‐seven cases of infection by H1N1 were confirmed by RT‐PCR and enrolled. Of these 57 cases, 26 had a severe H1N1 infection (group 1), and 31 had a mild H1N1 infection (group 2). Sera from 18 cases with pneumonia without H1N1 infection (group 3) were used as controls. The serum levels of 10 cytokines were determined by multiplex assay. RESULTS: The serum levels of IFN‐α, IL‐6, and IP‐10 were significantly higher in H1N1 infected cases than in group 3, and levels of IL‐6 and IP‐10 were significantly higher in group 1 than in group 2. The level of IL‐10 was significantly higher in groups 1 and 3 than in group 2. However, levels of IFN‐γ and IL‐17 were not significantly different between the three groups. IL‐1β, IL‐4, and MIP‐1α were not detectable in most patients. IP‐10 and IL‐6 levels were found to show negative correlations with lymphocyte count and oxygen saturation. CONCLUSIONS: We found higher levels of cytokines (IFN‐α, IL‐6, IP‐10) of innate immunity than those of acquired immunity in pediatric H1N1 infection. Of the cytokines found to be increased in cases with H1N1 infection, IP‐10 and IL‐6 were found to be correlated with disease severity (lymphopenia and hypoxia). IP‐10 and IL‐6 may be important markers in pediatric H1N1 infection. Pediatr Pulmonol. 2011; 46: 1233–1239. © 2011 Wiley Periodicals, Inc.
has issue date	2011-05-27(xsd:dateTime)
bibo:doi	10.1002/ppul.21496
bibo:pmid	21626718
has license	no-cc
sha1sum (hex)	be26eef28285ced8d2141e36ec9c003f31f8bdae
schema:url	https://doi.org/10.1002/ppul.21496
resource representing a document's title	Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection
has PubMed Central identifier	PMC7167952
has PubMed identifier	21626718
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:be26eef28285ced8d2141e36ec9c003f31f8bdae#body_text
is schema:about of	named entity 'serum' named entity 'Sera' named entity 'influenza' named entity 'lymphopenia' named entity 'cases' named entity 'infection' named entity 'levels' named entity 'cytokines' named entity 'patients' named entity 'Virus' named entity 'Pandemic Influenza' named entity 'H1N1' named entity '2009' named entity 'INFLUENZA H1N1' named entity 'PATIENTS' named entity 'CORRELATED' named entity 'IL-1B' named entity 'BUT' named entity 'OXYGEN SATURATION' named entity 'LEVELS' named entity 'FINDINGS' named entity 'GROUP 2' named entity 'CYTOKINE ' named entity 'COMPARISON' named entity 'controls' named entity 'H1N1' named entity 'levels' named entity 'H1N1' named entity 'hypoxia' named entity 'negative' named entity 'pneumonia' named entity 'H1N1' named entity 'H1N1' named entity 'patients' named entity 'serum' named entity 'IL-6' named entity 'acquired immunity' named entity 'pediatric' named entity 'H1N1' named entity 'group 1' named entity 'IL-4' named entity 'multiplex' named entity 'cases' named entity 'cytokines' named entity 'laboratory' named entity 'levels' named entity 'disease' named entity 'confirmed' named entity 'RT-PCR' named entity 'H1N1' named entity 'pneumonia' named entity 'infection' named entity 'hypoxia' named entity 'lymphopenia' named entity 'H1N1 infection' named entity 'IP-10' named entity 'IL-6' named entity 'oxygen saturation' named entity 'virus' named entity 'H1N1 infection' named entity 'innate immunity' named entity 'infection' named entity 'H1N1 infection' named entity 'MIP-1a' named entity 'H1N1' named entity 'Infection' named entity 'Pediatric' named entity 'H1N1 2009' named entity 'pneumonia' named entity 'RT-PCR' named entity 'pro-inflammatory' named entity 'infection' named entity 'IL-4' named entity 'reverse transcription polymerase chain reaction' named entity 'IL-6' named entity 'H1N1 2009' named entity 'acute respiratory distress syndrome' named entity 'corticosteroid' named entity 'immunomodulatory'

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