About: Dendritic cells: Immunological sentinels with a central role in health and disease

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About: Dendritic cells: Immunological sentinels with a central role in health and disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dendritic cells: Immunological sentinels with a central role in health and disease
Creator	Blair, G Mcgonagle, Dennis Blair, Eric Martin, Iain Stockwin, Luke
topic	covid:be48a509300c6920dd211aec21224efffd0e638a#this
Source	Medline; PMC
abstract	Immunological effector cells must be sensitive to the antigens or environmental signals that indicate that a pathogen is present. To this end, a group of cells known as the professional antigen‐presenting cells have the ability to educate T, B and NK cells as to the fingerprints of specific infections. The most adept of these cells are a closely related family termed dendritic cells (DC). A subset of these act as peripheral sentinels, specializing in the uptake, processing and presentation of antigenic material combined with an ability to detect a wide variety of ‘danger’ signals. These ‘danger’ or activation signals induce profound changes in dendritic cell physiology, facilitating the efficient stimulation of both adaptive and innate immunity. In the present review, a number of recent advances in the understanding of DC biology are discussed. These advances offer insights into the pathogenesis of a wide variety of diseases and point towards future strategies for immunotherapy.
has issue date	2000-04-01(xsd:dateTime)
bibo:doi	10.1046/j.1440-1711.2000.00888.x
bibo:pmid	10762408
has license	no-cc
sha1sum (hex)	be48a509300c6920dd211aec21224efffd0e638a
schema:url	https://doi.org/10.1046/j.1440-1711.2000.00888.x
resource representing a document's title	Dendritic cells: Immunological sentinels with a central role in health and disease
has PubMed Central identifier	PMC7159383
has PubMed identifier	10762408
schema:publication	Immunol Cell Biol
resource representing a document's body	covid:be48a509300c6920dd211aec21224efffd0e638a#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/be48a509300c6920dd211aec21224efffd0e638a
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