About: COVID-19 in persons with haematological cancers

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 in persons with haematological cancers
Creator	Li, Lei Liang, Bo Chen, • Li, • Robert, • Wu, • Chen, Wenlan Chen, Zhichao Fang, Yun He, Wenjuan Li, Qiubai Lu, Xiaoting Ma, Yanling Wang, Hongxiang Yuan, Guolin Gale, Peter
Source	Medline; PMC
abstract	Infection with SARS-CoV-2, the cause of coronavirus infectious disease–19 (COVID-19), has caused a pandemic with >850,000 cases worldwide and increasing. Several studies report outcomes of COVID-19 in predominately well persons. There are also some data on COVID-19 in persons with predominately solid cancer but controversy whether these persons have the same outcomes. We conducted a cohort study at two centres in Wuhan, China, of 128 hospitalised subjects with haematological cancers, 13 (10%) of whom developed COVID-19. We also studied 226 health care providers, 16 of whom developed COVID-19 and 11 of whom were hospitalised. Co-variates were compared with the 115 subjects with haematological cancers without COVID-19 and with 11 hospitalised health care providers with COVID-19. There were no significant differences in baseline co-variates between subjects with haematological cancers developing or not developing COVID-19. Case rates for COVID-19 in hospitalised subjects with haematological cancers was 10% (95% Confidence Interval [CI], 6, 17%) compared with 7% (4, 12%; P = 0.322) in health care providers. However, the 13 subjects with haematological cancers had more severe COVID-19 and more deaths compared with hospitalised health care providers with COVID-19. Case fatality rates were 62% (32, 85%) and 0 (0, 32%; P = 0.002). Hospitalised persons with haematological cancers have a similar case rate of COVID-19 compared with normal health care providers but have more severe disease and a higher case fatality rate. Because we were unable to identify specific risk factors for COVID-19 in hospitalised persons with haematological cancers, we suggest increased surveillance and possible protective isolation.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1038/s41375-020-0836-7
bibo:pmid	32332856
has license	no-cc
sha1sum (hex)	be4abce142dd681901af73c72f91b7541171f87e
schema:url	https://doi.org/10.1038/s41375-020-0836-7
resource representing a document's title	COVID-19 in persons with haematological cancers
has PubMed Central identifier	PMC7180672
has PubMed identifier	32332856
schema:publication	Leukemia
resource representing a document's body	covid:be4abce142dd681901af73c72f91b7541171f87e#body_text
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