About: Multiple Sclerosis and Other Demyelinating Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple Sclerosis and Other Demyelinating Diseases
Creator	Soldan, Samantha Wu, Gregory Kolson, Dennis Markowitz, Clyde
Source	PMC
abstract	Multiple sclerosis (MS) is the most common idiopathic demyelinating disease of the central nervous system (CNS). Although partially effective treatments are now available, MS represents a major target for research into the development of disease-modifying therapies that specifically focus on the neuroimmune pathways of myelin and tissue damage that currently are incompletely understood. Multiple sclerosis is considered to be an example of development of autoimmunity to self-antigens within the CNS through multiple initiating events that include infections and other environmental factors. The direct or indirect induction of immune responses against CNS antigens includes chemotaxis of T cells, B cells, and monocytes, and production of immunoglobulin responses, each of which can act as an effector of myelin damage that occurs in distinct histological patterns. Because a specific cause for MS has not been identified, much MS research has focused on CNS immune responses triggered by unidentified insults that in turn trigger inflammation-mediated cascades of myelin and cellular damage that are likely relevant to other neurodegenerative diseases. This chapter discusses current the epidemiology, etiology, pathophysiology, animal models, virus models and recent advances in the neuroimmunology of MS from the perspective of the potential for development of newer therapies for MS and other inflammatory CNS diseases.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1007/978-0-387-72573-4_18
has license	no-cc
sha1sum (hex)	be97f70647ef3e7ffa8d274e7c72f1793dd719f3
schema:url	https://doi.org/10.1007/978-0-387-72573-4_18
resource representing a document's title	Multiple Sclerosis and Other Demyelinating Diseases
has PubMed Central identifier	PMC7120222
schema:publication	Neuroimmune Pharmacology
resource representing a document's body	covid:be97f70647ef3e7ffa8d274e7c72f1793dd719f3#body_text
is schema:about of	named entity 'Multiple Sclerosis' named entity 'demyelinating lesions' named entity 'microglial activation' named entity 'CCR5' named entity 'oligodendrocyte' named entity 'autoimmune disorders' named entity 'macrophage' named entity 'Avonex' named entity 'oligodendrocyte' named entity 'Theiler's virus' named entity 'oligodendrocyte' named entity 'cytokine' named entity 'New South Wales' named entity 'immune reaction' named entity 'eosinophils' named entity 'proinflammatory cytokines' named entity 'Ebers' named entity 'TMEV' named entity 'Neuromyelitis optica' named entity 'IL-17' named entity 'EAE' named entity 'organic solvents' named entity 'nodes of Ranvier' named entity 'TMEV' named entity 'Tregs' named entity 'EAE' named entity 'demyelination' named entity 'Caucasians' named entity 'demyelination' named entity 'CNS' named entity 'anti-CD20' named entity 'Faroe Islands' named entity 'cell trafficking' named entity 'T-cell' named entity 'environmental factors' named entity 'white blood cell count' named entity 'Poser' named entity 'murine models' named entity 'major histocompatibility complex' named entity 'demyelination' named entity 'T-cells' named entity 'viruses' named entity 'nitric oxide' named entity 'mice' named entity 'memory T-cells' named entity 'Uhthoff' named entity 'antigens' named entity 'autoimmunity' named entity 'glycoprotein' named entity 'brain and spinal cord' named entity 'demyelination' named entity 'cerebrospinal fluid' named entity 'endothelial cells' named entity 'Epidemiological' named entity 'matrix metalloproteinases' named entity 'treat patients' named entity 'epidemics' named entity 'genetic background' named entity 'MHC' named entity 'T-cell' named entity 'Poser' named entity 'etiology' named entity 'cytokine' named entity 'TH1 cells' named entity 'molecule' named entity 'markers of disease' named entity 'CCL2' named entity 'antigens' named entity 'CCR7' named entity 'BBB' named entity 'TMEV' named entity 'EAE' named entity 'pathogenesis' named entity 'rodent models' named entity 'lymph nodes' named entity 'Multiple sclerosis' named entity 'guinea pigs' named entity 'pathology' named entity 'etiology' named entity 'blood vessels'

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