About: Lower serum uric acid level predicts mortality in dialysis patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lower serum uric acid level predicts mortality in dialysis patients
Creator	Bae, Eunjin Cho, Hyun-Jeong Kang, Shin-Wook Kim, Yong-Lim Lee, Hajeong Shin, Nara Ho, Nam Kim, Dong Kim, Sun Kim, Yon Woo, Chul Yang, Hee
source	PMC
abstract	We evaluated the impact of serum uric acid (SUA) on mortality in patients with chronic dialysis. A total of 4132 adult patients on dialysis were enrolled prospectively between August 2008 and September 2014. Among them, we included 1738 patients who maintained dialysis for at least 3 months and had available SUA in the database. We categorized the time averaged-SUA (TA-SUA) into 5 groups: <5.5, 5.5–6.4, 6.5–7.4, 7.5–8.4, and ≥8.5 mg/dL. Cox regression analysis was used to calculate the hazard ratio (HR) of all-cause mortality according to SUA group. The mean TA-SUA level was slightly higher in men than in women. Patients with lower TA-SUA level tended to have lower body mass index (BMI), phosphorus, serum albumin level, higher proportion of diabetes mellitus (DM), and higher proportion of malnourishment on the subjective global assessment (SGA). During a median follow-up of 43.9 months, 206 patients died. Patients with the highest SUA had a similar risk to the middle 3 TA-SUA groups, but the lowest TA-SUA group had a significantly elevated HR for mortality. The lowest TA-SUA group was significantly associated with increased all-cause mortality (adjusted HR, 1.720; 95% confidence interval, 1.007–2.937; P = 0.047) even after adjusting for demographic, comorbid, nutritional covariables, and medication use that could affect SUA levels. This association was prominent in patients with well nourishment on the SGA, a preserved serum albumin level, a higher BMI, and concomitant DM although these parameters had no significant interaction in the TA-SUA-mortality relationship except DM. In conclusion, a lower TA-SUA level <5.5 mg/dL predicted all-cause mortality in patients with chronic dialysis.
has issue date	2016-06-17(xsd:dateTime)
bibo:doi	10.1097/md.0000000000003701
bibo:pmid	27310949
has license	cc-by
sha1sum (hex)	be9cb78bf2453f68b260e9ed4f75d9ceccb77754
schema:url	https://doi.org/10.1097/md.0000000000003701
resource representing a document's title	Lower serum uric acid level predicts mortality in dialysis patients
has PubMed Central identifier	PMC4998435
has PubMed identifier	27310949
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:be9cb78bf2453f68b260e9ed4f75d9ceccb77754#body_text
is schema:about of	named entity 'confidence interval' named entity 'patients' named entity 'CONFIDENCE INTERVAL' named entity '6.5' named entity 'RISK' named entity 'PATIENTS' named entity 'DIALYSIS' named entity 'ADULT' named entity 'GROUP' named entity 'PREDICTED' named entity 'TOTAL' named entity 'COX REGRESSION' named entity 'CONCLUSION' named entity 'COMORBID' named entity 'SUA' named entity 'SGA' named entity 'SERUM ALBUMIN LEVEL' named entity 'PROMINENT' named entity 'BODY MASS INDEX' named entity 'LOWEST' named entity 'MAINTAINED' named entity 'MIDDLE' named entity 'ADJUSTING' named entity 'PHOSPHORUS' named entity 'MEDICATION USE' named entity '8.4' named entity 'ALL-CAUSE MORTALITY' named entity 'LOWER' named entity 'WOMEN' named entity 'SERUM URIC ACID' named entity 'HAVE' named entity 'EVALUATED' named entity 'EXCEPT' named entity 'MEN' named entity 'IMPACT' named entity 'CATEGORIZED' named entity 'AUGUST' named entity 'A58' named entity 'MORTALITY' named entity 'SERUM URIC ACID LEVEL' named entity '6.4' named entity 'NUTRITIONAL' named entity 'CHRONIC DIALYSIS' named entity 'NOURISHMENT' named entity 'THESE' named entity 'INCLUDED' named entity 'MEAN' named entity 'ACCORDING' named entity '7.5' named entity 'BUT' named entity 'TO CALCULATE' named entity 'DIED' named entity 'DATABASE' named entity 'HIGHEST' named entity 'GROUPS' named entity 'ASSOCIATION' named entity 'AFFECT' named entity 'LOWER' named entity 'REGRESSION ANALYSIS' named entity 'TIME' named entity 'ASSOCIATED WITH' named entity 'PROPORTION' named entity 'AVAILABLE' named entity 'MEDIAN' named entity 'LEVEL' named entity '5-6' named entity 'INTERACTION' named entity '7.4' named entity '5.5' named entity 'SUBJECTIVE GLOBAL ASSESSMENT'

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