About: Cardiopulmonary failure in children infected with Enterovirus A71

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cardiopulmonary failure in children infected with Enterovirus A71
Creator	Lin, Tzou-Yien Chan, Oi-Wa Hsia, Shao-Hsuan Lin, Jainn-Jim
source	PMC
abstract	Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss the pathogenesis, clinical manifestations, management strategy, and clinical outcomes of cardiopulmonary failure (CPF) in patients with EV-A71 infection. The pathogenesis of CPF involves both catecholamine-related cardiotoxicity following brainstem encephalitis and vasodilatory shock due to cytokine storm. Sympathetic hyperactivity, including tachycardia and hypertension, are the early clinical manifestations of cardiopulmonary involvement, which may progress to pulmonary edema/hemorrhage and/or CPF. The management strategy comprises multidisciplinary supportive treatment, including fluid management, positive pressure ventilation support, and use of milrinone, vasopressors, and inotropes. Some patients may require extracorporeal membrane oxygenation. Major neurological sequelae are almost inevitable once a child develops life-threatening illness. Long-term care of these children is an important medico-social issue.
has issue date	2020-04-16(xsd:dateTime)
bibo:doi	10.1186/s12929-020-00650-1
bibo:pmid	32299443
has license	cc-by
sha1sum (hex)	bec0df56a9525ba837a2cf3e67831a3b2abb8d08
schema:url	https://doi.org/10.1186/s12929-020-00650-1
resource representing a document's title	Cardiopulmonary failure in children infected with Enterovirus A71
has PubMed Central identifier	PMC7161201
has PubMed identifier	32299443
schema:publication	J Biomed Sci
resource representing a document's body	covid:bec0df56a9525ba837a2cf3e67831a3b2abb8d08#body_text
is schema:about of	named entity 'child' named entity 'mouth' named entity 'strategy' named entity 'Enterovirus' named entity 'PATHOGENS' named entity 'HYPERACTIVITY' named entity 'EARLY' named entity 'positive pressure ventilation' named entity 'inotropes' named entity 'tachycardia' named entity 'cardiotoxicity' named entity 'disease' named entity 'pulmonary edema' named entity 'EV-A71' named entity 'patients' named entity 'left ventricle' named entity 'blood volume' named entity 'HFMD' named entity 'manifestations' named entity 'life-threatening' named entity 'EV-A71' named entity 'supportive treatment' named entity 'cytokine storm' named entity 'tachycardia' named entity 'inotropes' named entity 'HFMD' named entity 'positive pressure ventilation' named entity 'EV-A71' named entity 'pathogenesis' named entity 'hemorrhage' named entity 'heart failure' named entity 'HFMD' named entity 'ECMO' named entity 'virus infection' named entity 'systemic inflammatory response' named entity 'HFMD' named entity 'sepsis' named entity 'Asia-Pacific' named entity 'pulmonary artery catheterization' named entity 'randomized controlled trial' named entity 'cardiovascular' named entity 'systolic pressure' named entity 'cardiopulmonary failure' named entity 'cardiopulmonary function' named entity 'lungs' named entity 'hypotension' named entity 'oliguria' named entity 'central nervous' named entity 'enterovirus' named entity 'left ventricular' named entity 'contractility' named entity 'atelectasis' named entity 'herpangina' named entity 'pediatric intensive care unit' named entity 'EV71' named entity 'Taiwan' named entity 'hemorrhagic' named entity 'diuretics' named entity 'fraction of inspired oxygen' named entity 'capillary permeability' named entity 'lungs' named entity 'Myocardial injury' named entity 'neurodevelopment' named entity 'World Health Organization' named entity 'positive end-expiratory pressure' named entity 'myoclonic jerks' named entity 'epinephrine' named entity 'dopamine' named entity 'brainstem' named entity 'lethargy' named entity 'end-organ' named entity 'norepinephrine' named entity 'EV-A71' named entity 'proinflammatory cytokines' named entity 'apnea' named entity 'myocardium' named entity 'Denver Developmental Screening Test' named entity 'catecholamines'

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