About: Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage

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About: Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage
Creator	Wang, Lin Zhang, Wei Yang, Li Zhang, Ting Wang, Xiaojing Zhang, Ming Liu, Yao Chen, Zhihai Liu, Jingyuan Xiong, Haofeng Xu, Yanli Han, Bing Li, Ben Li, Chuansheng Pu, Lin Song, Meihua Song, Rui Tan, Jianbo Wang, Xianbo Wang, Yanbin Zhou, Guiqin
source	Medline; PMC
abstract	BACKGROUND: Patients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive factor for critical illness caused by COVID-19. METHODS: The study prospectively involved 61 patients with COVID-19 infection as a derivation cohort, and 54 patients as a validation cohort. The predictive factor for critical illness was selected using LASSO regression analysis. A nomogram based on non-specific laboratory indicators was built to predict the probability of critical illness. RESULTS: The neutrophil-to-lymphocyte ratio (NLR) was identified as an independent risk factor for critical illness in patients with COVID-19 infection. The NLR had an area under receiver operating characteristic of 0.849 (95% confidence interval [CI], 0.707 to 0.991) in the derivation cohort and 0.867 (95% CI 0.747 to 0.944) in the validation cohort, the calibration curves fitted well, and the decision and clinical impact curves showed that the NLR had high standardized net benefit. In addition, the incidence of critical illness was 9.1% (1/11) for patients aged ≥ 50 and having an NLR < 3.13, and 50% (7/14) patients with age ≥ 50 and NLR ≥ 3.13 were predicted to develop critical illness. Based on the risk stratification of NLR according to age, this study has developed a COVID-19 pneumonia management process. CONCLUSIONS: We found that NLR is a predictive factor for early-stage prediction of patients infected with COVID-19 who are likely to develop critical illness. Patients aged ≥ 50 and having an NLR ≥ 3.13 are predicted to develop critical illness, and they should thus have rapid access to an intensive care unit if necessary.
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1186/s12967-020-02374-0
bibo:pmid	32434518
has license	cc-by
sha1sum (hex)	bf6a1e90880b3d0dd31da8abb858d55650159cc9
schema:url	https://doi.org/10.1186/s12967-020-02374-0
resource representing a document's title	Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage
has PubMed Central identifier	PMC7237880
has PubMed identifier	32434518
schema:publication	J Transl Med
resource representing a document's body	covid:bf6a1e90880b3d0dd31da8abb858d55650159cc9#body_text
is schema:about of	named entity 'Patients' named entity 'CAUSED BY' named entity 'USEFUL' named entity 'CORONAVIRUS DISEASE' named entity 'BACKGROUND' named entity 'COVID-19' named entity 'coronavirus' named entity 'critical illness' named entity 'caused by COVID-19' named entity 'moderate group' named entity 'urea' named entity 'risk stratification' named entity 'COVID-19' named entity 'critical illness' named entity 'COVID' named entity 'mmHg' named entity 'Wuhan' named entity 'NLR' named entity 'blood samples' named entity 'hypertension' named entity 'probability' named entity 'NLR' named entity 'ICU' named entity 'acute respiratory failure' named entity 'chest radiograph' named entity 'infection' named entity 'NLR' named entity 'respiratory failure' named entity 'H1N1' named entity 'pneumonia' named entity 'COVID' named entity 'COVID' named entity 'ICU' named entity 'white blood cell count' named entity 'LASSO regression' named entity 'Influenza A virus' named entity 'critical illness' named entity 'respiratory tract' named entity 'CURB-65' named entity 'resting state' named entity 'critically ill patients' named entity 'oxygen support' named entity 'creatinine' named entity 'shortness of breath' named entity 'proportional hazards regression' named entity 'pneumonia' named entity 'critical illness' named entity 'pneumonia' named entity 'receiver operating characteristic analysis' named entity 'Wuhan' named entity 'NLR' named entity 'significant difference' named entity 'NLR' named entity 'pneumonia' named entity 'COVID' named entity 'serum' named entity 'probability' named entity 'signs, symptoms' named entity 'Austria' named entity 'NLR' named entity 'epidemiological'

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