About: LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins 1 1 Edited by F. E. Cohen

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About: LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins 1 1 Edited by F. E. Cohen Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins 1 1 Edited by F. E. Cohen
Creator	Berger, Bonnie Kim, Peter Singh, Mona
Source	Elsevier; Medline; PMC
abstract	Abstract Crystallographic studies have shown that the coiled-coil motif occurs in several viral membrane-fusion proteins, including HIV-1 gp41 and influenza virus hemagglutinin. Here, the LearnCoil-VMF program was designed as a specialized program for identifying coiled-coil-like regions in viral membrane-fusion proteins. Based upon the use of LearnCoil-VMF, as well as other computational tools, we report detailed sequence analyses of coiled-coil-like regions in retrovirus, paramyxovirus and filovirus membrane-fusion proteins. Additionally, sequence analyses of these proteins outside their putative coiled-coil domains illustrate some structural differences between them. Complementing previous crystallographic studies, the coiled-coil-like regions detected by LearnCoil-VMF provide further evidence that the three-stranded coiled coil is a common motif found in many diverse viral membrane-fusion proteins. The abundance and structural conservation of this motif, even in the absence of sequence homology, suggests that it is critical for viral-cellular membrane fusion. The LearnCoil-VMF program is available at http://web.wi.mit.edu/kim
has issue date	1999-07-30(xsd:dateTime)
bibo:doi	10.1006/jmbi.1999.2796
bibo:pmid	10438601
has license	els-covid
sha1sum (hex)	bfad9c0dc5f577176419ed4d0bbb263e7c5ab072
schema:url	https://doi.org/10.1006/jmbi.1999.2796
resource representing a document's title	LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins 1 1 Edited by F. E. Cohen
has PubMed Central identifier	PMC7125536
has PubMed identifier	10438601
schema:publication	Journal of Molecular Biology
resource representing a document's body	covid:bfad9c0dc5f577176419ed4d0bbb263e7c5ab072#body_text
is schema:about of	named entity 'Viral' named entity 'COMPUTATIONAL EVIDENCE' named entity 'EVIDENCE FOR' named entity 'FUSION' named entity 'LIKE' named entity 'VIRAL MEMBRANE' named entity 'COILED-COIL' named entity 'MOTIFS' named entity 'VMF' named entity 'PROTEINS' named entity 'envelope proteins' named entity 'X-ray crystal structures' named entity 'cleavage site' named entity 'Harbury' named entity 'viral membrane' named entity 'fusion peptide' named entity 'Marburg virus' named entity 'motif' named entity 'bovine' named entity 'enveloped viruses' named entity 'C-terminal' named entity 'helical' named entity 'baculovirus' named entity 'coiled-coil region' named entity 'helical bundle' named entity 'heptad repeat' named entity 'helix' named entity 'viral membrane' named entity 'PDB' named entity 'C-terminal' named entity 'coiled-coil regions' named entity 'virus envelope' named entity 'Ebola' named entity 'fusion proteins' named entity 'fusion proteins' named entity 'coiled coil' named entity 'coiled-coil structure' named entity 'paramyxovirus' named entity 'FIV' named entity 'heptad repeat' named entity 'Weissenhorn' named entity 'coiled-coil' named entity 'coiled-coil' named entity 'retroviruses' named entity 'N-terminal' named entity 'interact' named entity 'coiled-coil' named entity 'glycoprotein' named entity 'cleavage site' named entity 'Rous sarcoma' named entity 'envelope proteins' named entity 'fusion proteins' named entity 'fusion proteins' named entity 'coiled-coil' named entity 'coiled-coil' named entity 'protein' named entity 'spike protein' named entity 'sequence similarity' named entity 'gp41' named entity 'coiled-coil' named entity 'equine infectious anemia' named entity 'Iterative approaches' named entity 'coiled-coil' named entity 'lentiviruses' named entity 'coiled coil' named entity 'dominant-negative' named entity 'heptad' named entity 'coiled coil' named entity 'helix' named entity 'vary considerably' named entity 'Ebola' named entity 'cartilage' named entity 'PDB' named entity 'trimer' named entity 'caprine arthritis encephalitis virus' named entity 'SIV' named entity 'fusion peptide' named entity 'peptides' named entity 'peptides'

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