About: Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation

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About: Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation
Creator	Higuera, Angelica Baron, Rebecca Cho, Michael Dieffenbach, Paul Englert, Joshua Fredenburgh, Laura Lamb, Andrew Basil, Maria Ho, Vincent Bhatt, Ami Soiffer, Robert Antin, Joseph Barragan-Bradford, Diana Himes, Blanca Howrylak, Judie Isabelle, Colleen Kang, Joyce Shumyatcher, Maya Vera, Mayra
Source	PMC
abstract	BACKGROUND: The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortality. Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for ARDS. We hypothesized that HSCT patients with ARDS would have a unique transcriptomic profile identifiable in peripheral blood compared to those that did not undergo HSCT. METHODS: We isolated RNA from banked peripheral blood samples from a biorepository of critically ill ICU patients. RNA-Seq was performed on 11 patients with ARDS (5 that had undergone HSCT and 6 that had not) and 12 patients with sepsis without ARDS (5 that that had undergone HCST and 7 that had not). RESULTS: We identified 687 differentially expressed genes between ARDS and ARDS-HSCT (adjusted p-value < 0.01), including IFI44L, OAS3, LY6E, and SPATS2L that had increased expression in ARDS vs. ARDS-HSCT; these genes were not differentially expressed in sepsis vs sepsis-HSCT. Gene ontology enrichment analysis revealed that many differentially expressed genes were related to response to type I interferon. CONCLUSIONS: Our findings reveal significant differences in whole blood transcriptomic profiles of patients with non-HSCT ARDS compared to ARDS-HSCT patients and point toward different immune responses underlying ARDS and ARDS-HSCT that contribute to lung injury. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-019-0981-6) contains supplementary material, which is available to authorized users.
has issue date	2019-01-21(xsd:dateTime)
bibo:doi	10.1186/s12931-019-0981-6
bibo:pmid	30665420
has license	cc-by
sha1sum (hex)	bfba248eee613d74a172381f5f645bd7060d8433
schema:url	https://doi.org/10.1186/s12931-019-0981-6
resource representing a document's title	Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation
has PubMed Central identifier	PMC6341764
has PubMed identifier	30665420
schema:publication	Respir Res
resource representing a document's body	covid:bfba248eee613d74a172381f5f645bd7060d8433#body_text
is schema:about of	named entity 'high' named entity 'patients' named entity 'ARDS' named entity 'HSCT' named entity 'identifiable' named entity 'unique' named entity 'hypothesized' named entity 'HSCT' named entity 'hypoxemia' named entity 'ARDS' named entity 'HSCT' named entity 'hypoxemia' named entity 'transcriptomic' named entity 'acute respiratory distress syndrome' named entity 'hematopoietic stem cell transplantation' named entity 'transcriptomic' named entity 'OAS3' named entity 'lung injury' named entity 'ARDS' named entity 'ARDS' named entity 'OAS2' named entity 'idiopathic' named entity 'immune response' named entity 'ARDS' named entity 'HSCT' named entity 'ARDS' named entity 'ARDS' named entity 'gene expression' named entity 'RNA-Seq' named entity 'interferon' named entity 'statistical significance' named entity 'ARDS' named entity 'ARDS' named entity 'ARDS' named entity 'ARDS' named entity 'cell types' named entity 'pathogens' named entity 'corticosteroids' named entity 'infliximab' named entity 'ARDS' named entity 'ARDS' named entity 'etanercept' named entity 'RNA' named entity 'sepsis' named entity 'confounders' named entity 'sepsis' named entity 'ARDS' named entity 'differentially expressed genes' named entity 'pneumonia' named entity 'HSCT' named entity 'blood samples' named entity 't-test' named entity 'HSCT' named entity 'sepsis' named entity 'ARDS' named entity 'cord blood' named entity 'ARDS' named entity 'acute respiratory failure' named entity 'interferon' named entity 'signaling pathways' named entity 'ARDS' named entity 'ICU' named entity 'ARDS'

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