About: Large granular leukemia with concurrent central nervous system and articular infiltration in a cat

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About: Large granular leukemia with concurrent central nervous system and articular infiltration in a cat Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Large granular leukemia with concurrent central nervous system and articular infiltration in a cat
Creator	Belluco, S Bouzouraa, T Cadoré, J.-L Chabanne, L Ponce, F Rannou, B Sayag, D Segard, E
Source	Elsevier; PMC
abstract	Summary A 2-year-old female domestic shorthair cat was referred with a 2month history of lethargy, weight loss, recurrent hyperthermia and polyarthropathy despite prednisolone. Upon physical examination, the cat showed apathy, hyperthermia, multiple appendicular joint pain and swelling. The CBC showed severe macrocytic normochromic non-regenerative anemia and thrombocytopenia. A population of immature large granular lymphocytes (LGL) was noted on blood smear. Abdominal ultrasonography revealed enlarged mesenteric lymph nodes (LNs), hyper echoic liver and splenomegaly. Cytology of fine needle aspirate of synovial fluid, spleen, liver, enlarged abdominal LNs and bone marrow supported a diagnosis of LGL leukemia with concurrent articular infiltration. A COP-based protocol was initiated with L-asparaginase (400 UI/kg intramuscularly) and prednisolone (1mg/kg/day orally). However, the cat presented 1 week later with obtundation and paresis, indicating the involvement of the central nervous system (CNS). LGL were also observed on cerebrospinal fluid analysis. Histologic examination noted LGL in the spleen, liver and LNs. Immunohistochemistry (IHC) yielded negative results for both B- and T-cells thus suggesting NK-cells. The diagnosis was LGL leukemia with concurrent articular and CNS involvement. Articular infiltration with LGL is rarely reported in small animals, whereas CNS involvement was previously only suspected in a cat at necropsy.
has issue date	2018-07-31(xsd:dateTime)
bibo:doi	10.1016/j.anicom.2018.06.002
has license	els-covid
sha1sum (hex)	bfbb895a0bc33703da75007a1052a4b7967eaede
schema:url	https://doi.org/10.1016/j.anicom.2018.06.002
resource representing a document's title	Large granular leukemia with concurrent central nervous system and articular infiltration in a cat
has PubMed Central identifier	PMC7148674
schema:publication	Revue Vétérinaire Clinique
resource representing a document's body	covid:bfbb895a0bc33703da75007a1052a4b7967eaede#body_text
is schema:about of	named entity 'LARGE' named entity 'Abdominal ultrasonography' named entity 'apathy' named entity 'INFILTRATION' named entity 'MULTIPLE' named entity 'ARTICULAR' named entity 'NOTED' named entity 'CBC' named entity 'HISTORY OF' named entity 'REGENERATIVE ANEMIA' named entity 'SEVERE' named entity 'RECURRENT' named entity 'BLOOD SMEAR' named entity 'OLD' named entity 'ABDOMINAL' named entity 'PHYSICAL EXAMINATION' named entity 'DOMESTIC' named entity 'LGL LEUKEMIA' covid:arg/bfbb895a0bc33703da75007a1052a4b7967eaede named entity 'LIVER' named entity 'CAT' named entity 'YEAR' named entity 'POPULATION' named entity 'MACROCYTIC' named entity 'ARTICULAR' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'REFERRED' named entity 'SPLENOMEGALY' named entity 'MONTH' named entity 'LEUKEMIA' named entity 'SWELLING' named entity 'REVEALED' named entity 'CONCURRENT' named entity 'NON-' named entity 'APATHY' named entity 'NORMOCHROMIC' named entity 'FEMALE' named entity 'LARGE GRANULAR LYMPHOCYTES' named entity 'POLYARTHROPATHY' named entity 'JOINT PAIN' named entity 'ENLARGED' named entity 'FINE NEEDLE ASPIRATE' named entity 'INFILTRATION' named entity 'BONE MARROW' named entity 'CONCURRENT' named entity 'GRANULAR' named entity 'CAT' named entity 'PREDNISOLONE' named entity 'CYTOLOGY' named entity 'THROMBOCYTOPENIA' named entity 'SYNOVIAL FLUID' named entity 'DIAGNOSIS' named entity 'ABDOMINAL ULTRASONOGRAPHY' named entity 'LETHARGY' named entity 'HYPER' named entity 'IMMATURE' named entity 'LNS' named entity 'SUPPORTED' named entity 'WEIGHT LOSS' named entity 'SPLEEN' named entity 'ENLARGED MESENTERIC LYMPH NODES' named entity 'HYPERTHERMIA' named entity 'domestic shorthair cat' named entity 'enlarged' named entity 'splenomegaly' named entity 'hyperthermia' named entity 'pain and swelling' named entity 'splenomegaly' named entity 'Cytology' named entity 'physical examination' named entity 'lymphocytes' named entity 'LGL' named entity 'lethargy' named entity 'liver' named entity 'spleen' named entity 'prednisolone'

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