About: Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase

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About: Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase
Creator	Benito, Antoni Castro, Jessica Ribó, Marc Vert, Anna Vilanova, Maria
Source	Medline; PMC
abstract	Onconase is a ribonuclease that presents both antitumor and antiviral properties linked to its ribonucleolytic activity and represents a new class of RNA-damaging drugs. It has reached clinical trials for the treatment of several cancers and human papilloma virus warts. Onconase targets different RNAs in the cell cytosol but Onconase-treated cells present features that are different from a simple arrest of protein synthesis. We have used microarray-derived transcriptional profiling to identify Onconase-regulated genes in two ovarian cancer cell lines (NCI/ADR-RES and OVCAR-8). RT-qPCR analyses have confirmed the microarray findings. We have identified a network of up-regulated genes implicated in different signaling pathways that may explain the cytotoxic effects exerted by Onconase. Among these genes, activating transcription factor 3 (ATF3) plays a central role in the key events triggered by Onconase in treated cancer cells that finally lead to apoptosis. This mechanism, mediated by ATF3, is cell-type independent. Up-regulation of ATF3 may also explain the antiviral properties of this ribonuclease because this factor is involved in halting viral genome replication, keeping virus latency or preventing viral oncogenesis. Finally, Onconase-regulated genes are different from those affected by nuclear-directed ribonucleases.
has issue date	2016-12-27(xsd:dateTime)
bibo:doi	10.18632/oncotarget.14302
bibo:pmid	28035074
has license	cc-by
sha1sum (hex)	bfd8dbd39a258f0a769375e64f7bd8df0e757266
schema:url	https://doi.org/10.18632/oncotarget.14302
resource representing a document's title	Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase
has PubMed Central identifier	PMC5355296
has PubMed identifier	28035074
schema:publication	Oncotarget
resource representing a document's body	covid:bfd8dbd39a258f0a769375e64f7bd8df0e757266#body_text
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