About: The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV

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About: The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
Creator	Zhao, Yang Ye, Xiang Dunker, William Karijolich, John Shehata, Myriam Xie, Zhihang
Source	PMC
abstract	Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved RNA decay mechanism that has emerged as a potent cell-intrinsic restriction mechanism of retroviruses and positive-strand RNA viruses. However, whether NMD is capable of restricting DNA viruses is not known. The DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma and primary effusion lymphoma (PEL). Here, we demonstrate that NMD restricts KSHV lytic reactivation. Leveraging high-throughput transcriptomics we identify NMD targets transcriptome-wide in PEL cells and identify host and viral RNAs as substrates. Moreover, we identified an NMD-regulated link between activation of the unfolded protein response and transcriptional activation of the main KSHV transcription factor RTA, itself an NMD target. Collectively, our study describes an intricate relationship between cellular targets of an RNA quality control pathway and KSHV lytic gene expression, and demonstrates that NMD can function as a cell intrinsic restriction mechanism acting upon DNA viruses.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1038/s41467-020-17151-2
bibo:pmid	32620802
has license	cc-by
sha1sum (hex)	bfe40403f3e518fc168b48ac6c140707f88bcbb7
schema:url	https://doi.org/10.1038/s41467-020-17151-2
resource representing a document's title	The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
has PubMed Central identifier	PMC7334219
has PubMed identifier	32620802
schema:publication	Nat Commun
resource representing a document's body	covid:bfe40403f3e518fc168b48ac6c140707f88bcbb7#body_text
is schema:about of	named entity 'DNA' named entity 'DNA' named entity 'NMD' named entity 'decay' named entity 'gene' named entity 'RTA' named entity 'RNAs' named entity 'KSHV' named entity 'cellular' named entity 'PEL' named entity 'NMD' named entity 'RNA' named entity 'evolutionarily conserved' named entity 'quality control' named entity 'transcriptome' named entity 'NMD' named entity 'primary effusion lymphoma' named entity 'viral RNAs' named entity 'NMD' named entity 'KSHV' named entity 'transcriptional activation' named entity 'gene clusters' named entity 'siRNA' named entity 'LANA' named entity 'NMD' named entity 'gencode' named entity '4A3' named entity 'KSHV' named entity 'long noncoding RNAs' named entity 'supernatants' named entity 'intronic' named entity 'NMD' named entity 'transcriptional activation' named entity 'FISH' named entity 'NMD' named entity 'transcription factor binding site' named entity 'RNA' named entity 'intron' named entity 'transfected' named entity '3′UTR' named entity 'DNA viruses' named entity 'BSA' named entity 'transfection' named entity 'NMD' named entity 'supernatant' named entity 'single-nucleotide' named entity 'tRNA' named entity 'Source Data' named entity 'XBP1' named entity 'formamide' named entity 'transfection' named entity 'NMD' named entity 'PEL' named entity 'viral genomes' named entity 'PEL' named entity 'doxycycline' named entity 'introns' named entity 'Chromatin immunoprecipitation' named entity 'GRCh38' named entity 'paired-end sequencing' named entity 'ftp' named entity 'etiological agent' named entity 'gene expression is regulated' named entity '3′UTR' named entity 'SDS-PAGE' named entity 'viral RNAs' named entity 'UPR' named entity 'eIF' named entity 'polycistronic' named entity 'introns' named entity 'lytic' named entity 'NMD' named entity 'intron' named entity 'lytic' named entity '3′UTR' named entity 'UPF1'

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