About: Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent Assay Using Recombinant VlsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing Using Whole-Cell Lysates

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About: Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent Assay Using Recombinant VlsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing Using Whole-Cell Lysates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent Assay Using Recombinant VlsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing Using Whole-Cell Lysates
Creator	Marques, Adriana Biggerstaff, Brad Gilmore, Robert Johnson, Barbara Murphree Bacon, Rendi Philipp, Mario Schriefer, Martin Steere, Allen Wormser, Gary
Source	PMC
abstract	In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorferi antigen VlsE1 (rVlsE1), IgG responses to a synthetic peptide homologous to a conserved internal sequence of VlsE (C6), and IgM responses to a synthetic peptide comprising the C-terminal 10 amino acid residues of a B. burgdorferi outer-surface protein C (pepC10) were evaluated by kinetic enzyme-linked immunoassay. At 99% specificity, the overall sensitivities for detecting IgG antibody to rVlsE1 or C6 in samples from patients with diverse manifestations of Lyme disease were equivalent to that of 2-tiered testing. When data were considered in parallel, 2 combinations (IgG responses to either rVlsE1 or C6 in parallel with IgM responses to pepC10) maintained high specificity (98%) and were significantly more sensitive than 2-tiered analysis in detecting antibodies to B. burgdorferi in patients with acute erythema migrans. In later stages of Lyme disease, the sensitivities of the in parallel tests and 2-tiered testing were high and statistically equivalent
has issue date	2003-04-15(xsd:dateTime)
bibo:doi	10.1086/374395
bibo:pmid	12695997
has license	no-cc
sha1sum (hex)	bfe768bccfb3d04816c2a5a1b1c1d58a39bb8dac
schema:url	https://doi.org/10.1086/374395
resource representing a document's title	Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent Assay Using Recombinant VlsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing Using Whole-Cell Lysates
has PubMed Central identifier	PMC7109709
has PubMed identifier	12695997
schema:publication	J Infect Dis
resource representing a document's body	covid:bfe768bccfb3d04816c2a5a1b1c1d58a39bb8dac#body_text
is schema:about of	named entity 'ANTIGENS' named entity 'RECOMBINANT' named entity 'COMPARED' named entity 'sensitive' named entity 'amino acid' named entity 'protein C' named entity 'CELL' named entity 'KINETIC' named entity 'DATA' named entity 'SPECIFICITY' named entity 'MAINTAINED' named entity 'PROTEIN C' named entity 'IGM' named entity 'SEQUENCE' named entity 'HOMOLOGOUS' named entity 'RESPONSES' named entity 'BORRELIA BURGDORFERI ANTIGEN' named entity 'IGG ANTIBODY' named entity 'KINETIC' named entity 'CONSIDERED' named entity 'EVALUATED' named entity 'MANIFESTATIONS' named entity 'STAGES' named entity 'SENSITIVE' named entity 'EQUIVALENT' named entity 'LYME DISEASE' named entity 'DETECTING' named entity 'ENZYME' named entity 'OVERALL' named entity 'CONSERVED' named entity 'PARALLEL' named entity 'LYME DISEASE' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'PEPTIDE' named entity 'SERODIAGNOSIS' named entity 'USING' named entity 'STATISTICALLY' named entity 'COMBINATIONS' named entity 'SYNTHETIC PEPTIDE' named entity 'INTERNAL' named entity 'BORRELIA BURGDORFERI' named entity 'TESTING' named entity 'TESTS' named entity 'IMMUNOASSAY' named entity 'AMINO ACID' named entity 'TESTING' named entity 'OUTER' named entity 'ACUTE ERYTHEMA' named entity 'SAMPLES' named entity 'LATER' named entity 'IGG' named entity 'DIVERSE' named entity 'EITHER' named entity 'HIGH' named entity 'ERYTHEMA MIGRANS' named entity 'ANALYSIS' named entity 'C-TERMINAL' named entity 'ANTIBODIES' named entity 'SURFACE PROTEIN' named entity 'PATIENTS' covid:arg/bfe768bccfb3d04816c2a5a1b1c1d58a39bb8dac named entity 'B. burgdorferi' named entity 'responses' named entity 'acid' named entity 'high' named entity 'testing' named entity 'detecting' named entity 'IgG' named entity 'evaluated' named entity 'detecting' named entity 'Testing' named entity 'Lyme Disease' named entity 'amino acid residues'

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