About: Shrinkage of Genome Size in a Plant RNA Virus upon Transfer of an Essential Viral Gene into the Host Genome

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About: Shrinkage of Genome Size in a Plant RNA Virus upon Transfer of an Essential Viral Gene into the Host Genome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Shrinkage of Genome Size in a Plant RNA Virus upon Transfer of an Essential Viral Gene into the Host Genome
Creator	Forment, Javier Tromas, Nicolas Elena, Santiago Zwart, Mark
Source	Medline; PMC
abstract	Nonretroviral integrated RNA viruses (NIRVs) are genes of nonretroviral RNA viruses found in the genomes of many eukaryotic organisms. NIRVs are thought to sometimes confer virus resistance, meaning that they could impact spread of the virus in the host population. However, a NIRV that is expressed may also impact the evolution of virus populations within host organisms. Here, we experimentally addressed the evolution of a virus in a host expressing a NIRV using Tobacco etch virus (TEV), a plant RNA virus, and transgenic tobacco plants expressing its replicase, NIb. We found that a virus missing the NIb gene, TEV-ΔNIb, which is incapable of autonomous replication in wild-type plants, had a higher fitness than the full-length TEV in the transgenic plants. Moreover, when the full-length TEV was evolved by serial passages in transgenic plants, we observed genomic deletions within NIb—and in some cases the adjacent cistrons—starting from the first passage. When we passaged TEV and TEV-ΔNIb in transgenic plants, we found mutations in proteolytic sites, but these only occurred in TEV-ΔNIb lineages, suggesting the adaptation of polyprotein processing to altered NIb expression. These results raise the possibility that NIRV expression can indeed induce the deletion of the corresponding genes in the viral genome, resulting in the formation of viruses that are replication defective in hosts that do not express the same NIRV. Moreover, virus genome evolution was contingent upon the deletion of the viral replicase, suggesting NIRV expression could also alter patterns of virus evolution.
has issue date	2014-02-20(xsd:dateTime)
bibo:doi	10.1093/gbe/evu036
bibo:pmid	24558257
has license	cc-by-nc
sha1sum (hex)	bfffc49744be05481a8a3d0266b38c8c2a816f14
schema:url	https://doi.org/10.1093/gbe/evu036
resource representing a document's title	Shrinkage of Genome Size in a Plant RNA Virus upon Transfer of an Essential Viral Gene into the Host Genome
has PubMed Central identifier	PMC3971587
has PubMed identifier	24558257
schema:publication	Genome Biol Evol
resource representing a document's body	covid:bfffc49744be05481a8a3d0266b38c8c2a816f14#body_text
is schema:about of	named entity 'OCCURRED' named entity 'PATTERNS' named entity 'GENE' named entity 'GENOMIC' named entity 'EUKARYOTIC' named entity 'BUT' named entity 'VIRUS RESISTANCE' named entity 'HERE' named entity 'PROTEOLYTIC' named entity 'EXPRESSION' named entity 'TEV' named entity 'HOST POPULATION' named entity 'TRANSGENIC TOBACCO' named entity 'PASSAGE' named entity 'ADAPTATION' named entity 'INTEGRATED' named entity 'VIRUS' named entity 'OBSERVED' named entity 'DEFECTIVE' named entity 'REPLICATION' named entity 'GENOME EVOLUTION' named entity 'MEANING' named entity 'RESULTING IN' named entity 'SERIAL' named entity 'PLANT RNA' named entity 'RNA VIRUSES' named entity 'ITS' named entity 'SPREAD' named entity 'THOUGHT' named entity 'HIGHER' named entity 'POLYPROTEIN' named entity 'GENES' named entity 'eukaryotic' named entity 'express' named entity 'deletion' named entity 'plant' named entity 'host' named entity 'viruses' named entity 'Genome' named entity 'VIRAL GENE' named entity 'TOBACCO ETCH VIRUS' named entity 'TRANSFER' named entity 'RESULTS' named entity 'VIRAL' named entity 'DO NOT' named entity 'SITES' named entity 'FITNESS' named entity 'VIRAL GENOME' named entity 'ALTERED' named entity 'RNA VIRUS' named entity 'GENOME' named entity 'PLANT RNA' named entity 'SHRINKAGE' named entity 'GENOME SIZE' named entity 'HOST' named entity 'CONTINGENT' named entity 'RNA VIRUS' named entity 'VIRUSES' named entity 'TRANSGENIC PLANTS' named entity 'IMPACT' named entity 'GENOMES' named entity 'LENGTH' named entity 'FORMATION' named entity 'AUTONOMOUS' named entity 'PROCESSING' named entity 'EXPRESSED' named entity 'EXPRESS' named entity 'INCAPABLE' named entity 'MISSING' named entity 'EVOLVED' named entity 'HOST' named entity 'ESSENTIAL' named entity 'INDUCE' named entity 'STARTING' named entity 'ORGANISMS' named entity 'WILD-TYPE' named entity 'ADJACENT' named entity 'POSSIBILITY'

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