About: The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins

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About: The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins
Creator	Aljabr, Waleed Armstrong, Stuart Cloutman-Green, Elaine Touzelet, Olivier Broadbent, Lindsay Power, Ultan Correspondence, Julian
Source	PMC
abstract	The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. However, the consequences of hRSV infection on epithelium secretome polarity and content remain poorly understood. To investigate the hRSV-associated apical and basolateral secretomes, a proteomics approach was combined with an ex vivo pediatric human airway epithelial (HAE) model of hRSV infection (data are available via ProteomeXchange and can be accessed at https://www.ebi.ac.uk/pride/ with identifier PXD013661). Following infection, a skewing of apical/basolateral abundance ratios was identified for several individual proteins. Novel modulators of neutrophil and lymphocyte activation (CXCL6, CSF3, SECTM1 or CXCL16), and antiviral proteins (BST2 or CEACAM1) were detected in infected, but not in uninfected cultures. Importantly, CXCL6, CXCL16, CSF3 were also detected in nasopharyngeal aspirates (NPA) from hRSV-infected infants but not healthy controls. Furthermore, the antiviral activity of CEACAM1 against RSV was confirmed in vitro using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium.
has issue date	2020-02-19(xsd:dateTime)
bibo:doi	10.1074/mcp.ra119.001546
bibo:pmid	32075873
has license	cc-by
sha1sum (hex)	c04aef60b135a7b2fa8397ee78668c18c69073c0
schema:url	https://doi.org/10.1074/mcp.ra119.001546
resource representing a document's title	The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins
has PubMed Central identifier	PMC7196588
has PubMed identifier	32075873
schema:publication	Mol Cell Proteomics
resource representing a document's body	covid:c04aef60b135a7b2fa8397ee78668c18c69073c0#body_text
is schema:about of	named entity 'biomarkers' named entity 'basolateral' named entity 'Profiling' named entity 'ratios' named entity 'paediatric' named entity 'Antiviral' named entity 'Identified' named entity 'hRSV' named entity 'CEACAM1' named entity 'CXCL16' named entity 'CSF3' named entity 'CEACAM1' named entity 'Pediatric' named entity 'hRSV' named entity 'BALF' named entity 'virus infections' named entity 'viral replication' named entity 'search engine' named entity 'CXCL6' named entity 'LFQ' named entity 'CXCL6' named entity 'signal peptide' named entity 'lung' named entity 'monoclonal antibodies' named entity 'hRSV' named entity 'hRSV' named entity 'bioinformatics' named entity 'pathogenesis' named entity 'MUC13' named entity 'Exosome' named entity 'virus' named entity 'peptide' named entity 'airway epithelium' named entity 'protein' named entity 'infection' named entity 'transmembrane' named entity 'CXCL16' named entity 'formic acid' named entity 'hpi' named entity 'LC-MS/MS' named entity 'aspirates' named entity 'Clinical Specimen' named entity 'ThermoFisher Scientific' named entity 'hRSV' named entity 'LC-MS/MS' named entity 'epithelium' named entity 'LC-MS/MS' named entity 'hRSV' named entity 'human immunodeficiency virus' named entity 'CEACAM1' named entity 'HKU1' named entity 'polyclonal' named entity 'IgG' named entity 'sucrose' named entity 'hierarchical clustering' named entity 'hRSV' named entity 'MOI' named entity 'hierarchical clustering' named entity 'regression analysis' named entity 'alveolar' named entity 'extracellular' named entity 'MOI' named entity 'homeostatic' named entity 'o-glycosylation' named entity 'dry transfer' named entity 'secretion' named entity 'hRSV' named entity 'LFQ' named entity 'PBS' named entity 'epithelial' named entity 'hRSV' named entity 'IPF' named entity 'SLC2A2' named entity 'viruses' named entity 'apical surface'

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