About: Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies

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About: Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies
Creator	Celada, Franco Fenoglio, Daniela Kunkl, Annalisa Manca, Fabrizio Pira, Giuseppina
Source	PMC
abstract	Activation of a galactosidase-specific murine T hybridoma clone and of a human tetanus toxoid-specific T clone by antigen-presenting cells (APC) was used to evaluate the regulatory function of antibodies complexed with the relevant antigen. Complexed antigen, in fact, is taken up with high efficiency thanks to Fc receptors borne by APC. Antibody/antigen ratio in the complexes proved to be a critical parameter in enhancing antigen presentation. Complexes in moderate antibody excess provided optimal T cell activation independently of the physical state of the complexes (precipitated by a second antibody or solubilized by complement). Complexes in extreme antibody excess, on the contrary, did not yield T cell activation although taken up by APC efficiently. The effect of antibodies at extreme excess was observed with substimulatory dose of antigen (loss of potentiation) and with optimal dose of antigen (loss of stimulation). An excess of specific polyclonal antibodies hampers proteolytic degradation of antigen in vitro, supporting the view that a similar mechanism may operate within the APC that have internalized immune complexes in extreme antibody excess. The possibility that immune complex forming in extreme antibody excess may turn off the T cell response is proposed as a regulatory mechanism.
has issue date	1991-01-01(xsd:dateTime)
bibo:pmid	1985125
has license	cc-by-nc-sa
sha1sum (hex)	c055818c61327ee072c403cb911793c9c49ca7bf
resource representing a document's title	Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies
has PubMed Central identifier	PMC2118742
has PubMed identifier	1985125
schema:publication	J Exp Med
resource representing a document's body	covid:c055818c61327ee072c403cb911793c9c49ca7bf#body_text
is schema:about of	named entity 'PROTEOLYTIC' named entity 'TAKEN' named entity 'MECHANISM' named entity 'DEGRADATION' named entity 'SECOND' named entity 'PROPOSED' named entity 'T CELL ACTIVATION' named entity 'REGULATORY' named entity 'CLONE' named entity 'OPTIMAL DOSE' named entity 'POTENTIATION' named entity 'SUPPORTING' named entity 'IMMUNE COMPLEX' named entity 'YIELD' named entity 'ANTIGEN' named entity 'DOSE' named entity 'ENHANCING' named entity 'HAVE' named entity 'ANTIGEN-PRESENTING CELLS' named entity 'FC RECEPTORS' named entity 'EFFECT' named entity 'RATIO' covid:arg/c055818c61327ee072c403cb911793c9c49ca7bf named entity 'ANTIGEN' named entity 'SPECIFIC' named entity 'DID' named entity 'HIGH EFFICIENCY' named entity 'PHYSICAL STATE' named entity 'STIMULATION' named entity 'UPTAKE' named entity 'ACTIVATION' named entity 'POLYCLONAL ANTIBODIES' named entity 'ANTIBODY' named entity 'IN VITRO' named entity 'PRESENTATION' named entity 'T CELLS' named entity 'EFFECT' named entity 'PROCESSING' named entity 'GALACTOSIDASE' named entity 'FUNCTION' named entity 'ANTIBODIES' named entity 'TETANUS TOXOID' named entity 'EXCESS' named entity 'TURN OFF' named entity 'T CELL RESPONSE' named entity 'POSSIBILITY' named entity 'SIMILAR' named entity 'ANTIGEN PRESENTATION' named entity 'VIEW' named entity 'MODERATE' named entity 'COMPLEXES' named entity 'PROVIDED' named entity 'POLYCLONAL ANTIBODIES' named entity 'MACROPHAGE' named entity 'OBSERVED' named entity 'PARAMETER' named entity 'HUMAN' named entity 'BORNE' named entity 'ANTIBODY EXCESS' named entity 'RELEVANT' named entity 'COMPLEMENT' named entity 'MURINE' named entity 'OPTIMAL' named entity 'OPERATE' named entity 'CRITICAL' named entity 'USED' named entity 'RATIO' named entity 'HYBRIDOMA' named entity 'EVALUATE' named entity 'IMMUNE COMPLEXES' named entity 'APC' named entity 'EXTREME' named entity 'FORMING' named entity 'FACT' named entity 'antigen' named entity 'antibody' named entity 'antigen-presenting cells' named entity 'antigen' named entity 'antigen presentation'

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