About: The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis

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About: The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis
Creator	Azevedo, Vasco Ghosh, Preetam De Castro Oliveira, Letícia Gomes Alves, Leandro Jamal, Syed Jose, Carlo Kumar Jaiswal, Arun Oliveira, Freira Soares, Siomar Tiwari, Sandeep
Source	PMC
abstract	BACKGROUND: Spirochetal organisms of the Treponema genus are responsible for causing Treponematoses. Pathogenic treponemes is a Gram-negative, motile, spirochete pathogen that causes syphilis in human. Treponema pallidum subsp. endemicum (TEN) causes endemic syphilis (bejel); T. pallidum subsp. pallidum (TPA) causes venereal syphilis; T. pallidum subsp. pertenue (TPE) causes yaws; and T. pallidum subsp. Ccarateum causes pinta. Out of these four high morbidity diseases, venereal syphilis is mediated by sexual contact; the other three diseases are transmitted by close personal contact. The global distribution of syphilis is alarming and there is an increasing need of proper treatment and preventive measures. Unfortunately, effective measures are limited. RESULTS: Here, the genome sequences of 53 T. pallidum strains isolated from different parts of the world and a diverse range of hosts were comparatively analysed using pan-genomic strategy. Phylogenomic, pan-genomic, core genomic and singleton analysis disclosed the close connection among all strains of the pathogen T. pallidum, its clonal behaviour and showed increases in the sizes of the pan-genome. Based on the genome plasticity analysis of the subsets containing the subspecies T pallidum subsp. pallidum, T. pallidum subsp. endemicum and T. pallidum subsp. pertenue, we found differences in the presence/absence of pathogenicity islands (PAIs) and genomic islands (GIs) on subsp.-based study. CONCLUSIONS: In summary, we identified four pathogenicity islands (PAIs), eight genomic islands (GIs) in subsp. pallidum, whereas subsp. endemicum has three PAIs and seven GIs and subsp. pertenue harbours three PAIs and eight GIs. Concerning the presence of genes in PAIs and GIs, we found some genes related to lipid and amino acid biosynthesis that were only present in the subsp. of T. pallidum, compared to T. pallidum subsp. endemicum and T. pallidum subsp. pertenue.
has issue date	2020-01-10(xsd:dateTime)
bibo:doi	10.1186/s12864-019-6430-6
bibo:pmid	31924165
has license	cc-by
sha1sum (hex)	c068f4973ed86ac76e96b0087cbb9c3b31a92cbe
schema:url	https://doi.org/10.1186/s12864-019-6430-6
resource representing a document's title	The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis
has PubMed Central identifier	PMC6953169
has PubMed identifier	31924165
schema:publication	BMC Genomics
resource representing a document's body	covid:c068f4973ed86ac76e96b0087cbb9c3b31a92cbe#body_text
is schema:about of	named entity 'effective' named entity 'based' named entity 'Background' named entity 'Unfortunately' named entity 'genus' named entity 'SEQUENCES' named entity 'HOSTS' named entity 'GENOMIC ISLANDS' named entity 'HIGH' named entity 'TREATMENT' named entity 'ANALYSIS' named entity 'RESULTS' named entity 'BACKGROUND' named entity 'SEXUAL CONTACT' named entity 'INCREASES' named entity 'DISEASES' named entity 'SPIROCHETE' named entity 'CLONAL' named entity 'MOTILE' named entity 'GRAM-' named entity 'GENOMIC' covid:arg/c068f4973ed86ac76e96b0087cbb9c3b31a92cbe named entity 'diseases' named entity 'isolated' named entity 'TPE' named entity 'causing' named entity 'strains' named entity 'venereal' named entity 'Treponema' named entity 'organisms' named entity 'subspecies' named entity 'motile' named entity 'yaws' named entity 'genome' named entity 'endemic syphilis' named entity 'plasticity' named entity 'morbidity' named entity 'Treponematoses' named entity 'T. pallidum' named entity 'pinta' named entity 'plasticity' named entity 'Treponema pallidum' named entity 'genome' named entity 'pan-genome' named entity 'heatmap' named entity 'morphology' named entity 'distance matrix' named entity 'Pathogenicity islands' named entity 'catalyzes' named entity 'biosynthesis of fatty acids' named entity 'virulence' named entity 'T. pallidum' named entity 'immune response' named entity 'lesion' named entity 'phages' named entity 'T. pallidum' named entity 'plasticity' named entity 'venereal syphilis' named entity 'infection' named entity 'yaws' named entity 'syphilis' named entity 'T. pallidum' named entity 'horizontal gene transfer' named entity 'adaptive immune response' named entity 'Syphilis' named entity 'tRNA' named entity 'genomes' named entity 'modes of transmission' named entity 'T. pallidum' named entity 'symptom' named entity 'pinta' named entity 'syphilis'

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