About: The Role of the Intestinal Microbiota in the Pathogenesis of Necrotizing Enterocolitis

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About: The Role of the Intestinal Microbiota in the Pathogenesis of Necrotizing Enterocolitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Role of the Intestinal Microbiota in the Pathogenesis of Necrotizing Enterocolitis
Creator	Wang, Jin Bell, Brandon Grishin, Anatoly Ford, Henri Papillon, Stephanie
Source	Elsevier; Medline; PMC
abstract	Development of necrotizing enterocolitis (NEC) requires a susceptible host, typically a premature infant or an infant with congenital heart disease, enteral feedings and bacterial colonization. Although there is little doubt that microbes are critically involved in the pathogenesis of NEC, the identity of specific causative pathogens remains elusive. Unlike established normal adult gut microbiota, which is quite complex, uniform, and stable, early postnatal bacterial populations are simple, diverse, and fluid. These properties complicate studies aimed at elucidating characteristics of the gut microbiome that may play a role in the pathogenesis of NEC. A broad variety of bacterial, viral, and fungal species have been implicated in both clinical and experimental NEC. Frequently, however, the same species have also been found in physiologically matched healthy individuals. Clustered outbreaks of NEC, in which the same strain of a suspected pathogen is detected in several patients suggest, but do not prove, a causative relationship between the specific pathogen and the disease. Studies in Cronobacter sakazakii, the best characterized NEC pathogen, have demonstrated that virulence is not a property of a bacterial species as a whole, but rather a characteristic of certain strains, which may explain why the same species can be pathogenic or non-pathogenic. The fact that a given microbe may be innocuous in a full-term, yet pathogenic in a pre-term infant has led to the idea of opportunistic pathogens in NEC. Progress in understanding the infectious nature of NEC may require identifying specific pathogenic strains and unambiguously establishing their virulence in animal models.
has issue date	2013-05-01(xsd:dateTime)
bibo:doi	10.1053/j.sempedsurg.2013.01.002
bibo:pmid	23611609
has license	green-oa
sha1sum (hex)	c0906ab25c9872b8b349cdf70f9e2bea71e122d6
schema:url	https://doi.org/10.1053/j.sempedsurg.2013.01.002
resource representing a document's title	The Role of the Intestinal Microbiota in the Pathogenesis of Necrotizing Enterocolitis
has PubMed Central identifier	PMC3647029
has PubMed identifier	23611609
schema:publication	Seminars in Pediatric Surgery
resource representing a document's body	covid:c0906ab25c9872b8b349cdf70f9e2bea71e122d6#body_text
is schema:about of	named entity 'species' named entity 'bacterial' named entity 'colonization' named entity 'led' named entity 'host' named entity 'Enterocolitis' named entity 'REMAINS' named entity 'CLUSTERED' named entity 'UNDERSTANDING' named entity 'SPECIFIC' named entity 'INDIVIDUALS' named entity 'CHARACTERISTICS' named entity 'THEIR' named entity 'PREMATURE INFANT' named entity 'FULL-TERM' named entity 'DISEASE' named entity 'WHY' named entity 'PATIENTS' named entity 'PLAY' named entity 'ENTERAL FEEDINGS' named entity 'MICROBES' named entity 'NORMAL' named entity 'HOST' named entity 'THESE' named entity 'COMPLEX' named entity 'NEC' named entity 'BACTERIAL COLONIZATION' named entity 'DEVELOPMENT' named entity 'NON-' named entity 'STABLE' named entity 'FREQUENTLY' named entity 'RELATIONSHIP' named entity 'IDEA' named entity 'SUGGEST' named entity 'SUSCEPTIBLE' named entity 'CRONOBACTER SAKAZAKII' named entity 'FLUID' named entity 'VARIETY' named entity 'RATHER' named entity 'BROAD' named entity 'FACT' named entity 'SPECIES' named entity 'GIVEN' named entity 'ADULT GUT' named entity 'STRAINS' named entity 'PATHOGENIC' named entity 'CHARACTERISTIC' named entity 'NATURE' named entity 'TERM INFANT' named entity 'VIRAL' named entity 'IDENTITY' named entity 'PROPERTIES' named entity 'INTESTINAL MICROBIOTA' named entity 'DOUBT' named entity 'PROPERTY' named entity 'STRAIN' named entity 'LED' named entity 'ESTABLISHED' named entity 'GUT MICROBIOTA' named entity 'OPPORTUNISTIC PATHOGENS' named entity 'EARLY' named entity 'VIRULENCE' named entity 'PATHOGEN' named entity 'CERTAIN' named entity 'BEST' named entity 'BACTERIAL' named entity 'UNIFORM' named entity 'INFANT' named entity 'IDENTIFYING' named entity 'PROGRESS' named entity 'THE GUT' named entity 'POPULATIONS' named entity 'DO NOT' named entity 'COMPLICATE' named entity 'INFECTIOUS' named entity 'ROLE' named entity 'PATHOGENESIS'

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