About: Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site
Creator	Kanekiyo, Masaru Todd, John-Paul Rao, Srinivas Yamamoto, Takuya Mascola, John Meng, Geng Baxa, Ulrich Bu, Wei Narpala, Sandeep Cohen, Jeffrey Gordon, M Graham, Barney Joyce, M Koup, Richard Mcdermott, Adrian Nabel, Gary Rossmann, Michael Whittle, James
Source	Elsevier; Medline; PMC
abstract	Epstein-Barr virus (EBV) represents a major global health problem. Though it is associated with infectious mononucleosis and over 200,000 cancers annually worldwide, a vaccine is not available. The major target of immunity is EBV glycoprotein 350/220 (gp350) that mediates attachment to B cells through complement receptor 2 (CR2/CD21). Here, we created self-assembling nanoparticles that displayed different domains of gp350 in a symmetric array. By focusing presentation of the CR2-binding domain on nanoparticles, potent neutralizing antibodies were elicited in mice and non-human primates. The structurally designed nanoparticle vaccine improved vaccine-induced protection in a mouse model by targeting a functionally conserved site of vulnerability with 10- to 100-fold increased neutralization compared to soluble gp350. This rational approach to EBV vaccine design elicited potent neutralizing antibody responses by focusing on a conserved viral entry domain, a strategy that can be applied to other viruses.
has issue date	2015-08-01(xsd:dateTime)
bibo:doi	10.1016/j.cell.2015.07.043
bibo:pmid	26279189
has license	hybrid-oa
sha1sum (hex)	c0cf63f8bf9e265aad0cccce3540f8887f338a58
schema:url	https://doi.org/10.1016/j.cell.2015.07.043
resource representing a document's title	Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site
has PubMed Central identifier	PMC4757492
has PubMed identifier	26279189
schema:publication	Cell
resource representing a document's body	covid:c0cf63f8bf9e265aad0cccce3540f8887f338a58#body_text
is schema:about of	named entity 'neutralizing antibodies' named entity 'vaccine' named entity 'soluble' named entity 'array' named entity 'EPSTEIN-BARR VIRUS' named entity 'BINDING SITE' named entity 'CANCERS' named entity 'SOLUBLE' named entity 'STRATEGY' named entity 'B CELLS' named entity 'SUMMARY' named entity '100' named entity 'DOMAIN' named entity 'GLOBAL HEALTH' named entity 'SITE' named entity 'ATTACHMENT' named entity 'CONSERVED' named entity 'PRESENTATION' named entity 'PRESENT' named entity 'BINDING' named entity '350' named entity 'ASSOCIATED WITH' named entity 'EBV' named entity 'HERE' named entity 'A MAJOR' named entity 'SITE OF' named entity 'RESPONSES' named entity 'TARGETING' named entity 'MOUSE MODEL' named entity 'DIFFERENT' named entity 'WORLDWIDE' named entity 'EPSTEIN-BARR VIRUS' named entity 'FOLD' named entity 'DESIGN' named entity 'CREATED' named entity 'MICE' named entity 'MEDIATES' named entity 'THESE' named entity 'INCREASED' named entity 'NEUTRALIZATION ' named entity 'VIRUS VACCINE' named entity 'TARGETING' named entity 'PRIMATES' named entity 'DISPLAYED' named entity 'APPLIED' named entity 'NEUTRALIZING ANTIBODY' named entity 'VULNERABILITY' named entity 'COMPARED' named entity 'RECEPTOR' named entity 'NOT AVAILABLE' named entity 'DESIGNED NANOPARTICLE' covid:arg/c0cf63f8bf9e265aad0cccce3540f8887f338a58 named entity 'SYMMETRIC' named entity 'VACCINE DESIGN' named entity 'ANNUALLY' named entity 'GLYCOPROTEIN' named entity 'ARTICLE' named entity 'NON-' named entity 'NANOPARTICLES' named entity 'FOCUSING' named entity 'ARRAY' named entity 'INFECTIOUS MONONUCLEOSIS' named entity 'TARGET' named entity 'HUMAN'

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