About: Open lung biopsy in early-stage acute respiratory distress syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Open lung biopsy in early-stage acute respiratory distress syndrome
Creator	Chen, Ning-Hung Hsieh, Meng-Jer Huang, Chung-Chi Tsai, Ying-Huang Huang, Shiu-Feng Kao, Kuo-Chin Wu, Yao-Kuang
source	PMC
abstract	INTRODUCTION: Acute respiratory distress syndrome (ARDS) has heterogeneous etiologies, rapid progressive change and a high mortality rate. To improve the outcome of ARDS, accurate diagnosis is essential to the application of effective early treatment. The present study investigated the clinical effects and safety of open lung biopsy (OLB) in patients with early-stage ARDS of suspected non-infectious origin. METHODS: We undertook a retrospective study of 41 patients with early-stage ARDS (defined as one week or less after intubation) who underwent OLB in two medical intensive care units of a tertiary care hospital from 1999 to 2005. Data analyzed included baseline characteristics, complication rate, pathological diagnoses, treatment alterations, and hospital survival. RESULTS: The age of patients was 55 ± 17 years (mean ± SD). The average ratio of arterial partial pressure of oxygen (PaO(2)) to fraction of inspired oxygen (FiO(2)) was 116 ± 43 mmHg (mean ± SD) at biopsy. Seventeen patients (41%) were immunocompromised. Postoperative complications occurred in 20% of patients (8/41). All biopsies provided a pathological diagnosis with a diagnostic yield of 100%. Specific pathological diagnoses were made for 44% of patients (18/41). Biopsy findings led to an alteration of treatment modality in 73% of patients (30/41). The treatment alteration rate was higher in patients with nonspecific diagnoses than in patients with specific diagnoses (p = 0.0024). Overall mortality was 50% (21/41) and was not influenced by age, gender, pre-OLB oxygenation, complication rate, pathological results, and alteration of treatment. There was no surgery-related mortality. The survival rate for immunocompromised patients was better than that for immunocompetent patients (71% versus 33%; p = 0.0187) in this study. CONCLUSION: Our retrospective study suggests that OLB was a useful and acceptably safe diagnostic procedure in some selected patients with early-stage ARDS.
has issue date	2006-07-19(xsd:dateTime)
bibo:doi	10.1186/cc4981
bibo:pmid	16859510
has license	cc-by
sha1sum (hex)	c0f8a4eef924cdeeeb5b17ae685760bf7cce9223
schema:url	https://doi.org/10.1186/cc4981
resource representing a document's title	Open lung biopsy in early-stage acute respiratory distress syndrome
has PubMed Central identifier	PMC1751007
has PubMed identifier	16859510
schema:publication	Crit Care
resource representing a document's body	covid:c0f8a4eef924cdeeeb5b17ae685760bf7cce9223#body_text
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