About: Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli
Creator	Moss, Bernard Koonin, Eugene Senkevich, Tatiana
source	Elsevier; Medline; PMC
abstract	The F16L gene of vaccinia virus (VACV) is conserved in all chordopoxviruses except avipoxviruses. The crocodile poxvirus F16 protein ortholog has highly significant similarity to prokaryotic serine recombinases and contains all amino acids that comprise the catalytic site. In contrast, F16 orthologs encoded by other poxviruses show only marginally significant similarity to serine recombinases, lack essential amino acids of the active site and are most likely inactive derivatives of serine recombinases. Nevertheless, the conservation of F16L in non-avian poxviruses suggested an important function. However, a VACV mutant with the F16L gene knocked out replicated normally in dividing and quiescent cells. The F16 protein was synthesized early after infection and detected in virus cores. When expressed in infected or uninfected cells, F16 accumulated in nucleoli depending on the level of expression and confluency of cells. Evidence was obtained that F16 forms multimers, which might regulate concentration-dependent intracellular localization.
has issue date	2011-09-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2011.06.017
bibo:pmid	21752417
has license	no-cc
sha1sum (hex)	c152d7732bc00c67a5d9a46c7c74b2da4e059189
schema:url	https://doi.org/10.1016/j.virol.2011.06.017
resource representing a document's title	Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli
has PubMed Central identifier	PMC3163719
has PubMed identifier	21752417
schema:publication	Virology
resource representing a document's body	covid:c152d7732bc00c67a5d9a46c7c74b2da4e059189#body_text
is schema:about of	named entity 'ortholog' named entity 'cells' named entity 'level' named entity 'prokaryotic' named entity 'knocked' named entity 'nucleoli' named entity 'expressed' named entity 'Vaccinia virus' named entity 'serine' named entity 'CORES' named entity 'SIGNIFICANT' named entity 'MOST LIKELY' named entity 'EARLY' named entity 'IMPORTANT' named entity 'VACV' named entity 'NON-' named entity 'RECOMBINASES' named entity 'CONSERVED' covid:arg/c152d7732bc00c67a5d9a46c7c74b2da4e059189 named entity 'virus' named entity 'protein' named entity 'However' named entity 'mutant' named entity 'protein' named entity 'gene' named entity 'predicted' named entity 'superfamily' named entity 'recombinases' named entity 'protein' named entity 'ortholog' named entity 'virus' named entity 'multimers' named entity 'nucleoli' named entity 'superfamily' named entity 'Vaccinia virus' named entity 'catalytic site' named entity '3′ end' named entity 'cytoplasmic' named entity 'Leica' named entity 'nucleolus' named entity 'NIH' named entity 'eukaryote' named entity 'nucleophosmin' named entity 'protein targeting' named entity 'Recombinant' named entity 'paraformaldehyde' named entity 'rRNA' named entity 'plasmids' named entity 'fibroblasts' named entity 'chordopoxvirus' named entity 'nucleoli' named entity 'primary cell' named entity 'reducing agent' named entity 'antibody' named entity 'HeLa cells' named entity 'human immunodeficiency virus' named entity 'click chemistry' named entity 'catalytic site' named entity 'cell culture' named entity 'PBS' named entity 'homology domain' named entity 'infection' named entity 'retroviruses' named entity 'site-specific recombination' named entity 'transposons' named entity 'protein' named entity 'nuclei' named entity 'Cytoplasmic extracts' named entity 'nucleoprotein' named entity 'nucleoli' named entity 'protein' named entity 'covalent' named entity 'poxviruses' named entity 'homology' named entity 'herpesviruses' named entity 'poxvirus' named entity 'virions' named entity 'bacteriophage' named entity 'horse radish'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software