About: Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection

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About: Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection
Creator	Regamey, Nicolas Casaulta, Carmen Geiser, Thomas Jung, Andreas Moeller, Alexander Schögler, Aline Edwards, Michael Johnston, Sebastian Alves, Marco Stokes, Andrea
Source	Elsevier; Medline; PMC
abstract	Abstract Rhinoviruses (RVs) are associated with exacerbations of cystic fibrosis (CF), asthma and COPD. There is growing evidence suggesting the involvement of the interferon (IFN) pathway in RV-associated morbidity in asthma and COPD. The mechanisms of RV-triggered exacerbations in CF are poorly understood. In a pilot study, we assessed the antiviral response of CF and healthy bronchial epithelial cells (BECs) to RV infection, we measured the levels of IFNs, pattern recognition receptors (PRRs) and IFN-stimulated genes (ISGs) upon infection with major and minor group RVs and poly(IC) stimulation. Major group RV infection of CF BECs resulted in a trend towards a diminished IFN response at the level of IFNs, PRRs and ISGs in comparison to healthy BECs. Contrary to major group RV, the IFN pathway induction upon minor group RV infection was significantly increased at the level of IFNs and PRRs in CF BECs compared to healthy BECs.
has issue date	2016-05-31(xsd:dateTime)
bibo:doi	10.1016/j.jcf.2015.10.013
bibo:pmid	26613982
has license	els-covid
sha1sum (hex)	c16dfeea09dfb1ecaba8f7b1b3fcf7fe687ecd66
schema:url	https://doi.org/10.1016/j.jcf.2015.10.013
resource representing a document's title	Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection
has PubMed Central identifier	PMC7185532
has PubMed identifier	26613982
schema:publication	Journal of Cystic Fibrosis
resource representing a document's body	covid:c16dfeea09dfb1ecaba8f7b1b3fcf7fe687ecd66#body_text
is schema:about of	named entity 'IFN' named entity 'BECs' named entity 'group' named entity 'level' named entity 'group' named entity 'infection' named entity 'GROUP' named entity 'RHINOVIRUS INFECTION' named entity 'ASSESSED' named entity 'GROWING' named entity 'DIMINISHED' covid:arg/c16dfeea09dfb1ecaba8f7b1b3fcf7fe687ecd66 named entity 'RESPONSE' named entity 'STIMULATED' named entity 'TREND' named entity 'POORLY' named entity 'INCREASED' named entity 'MORBIDITY' named entity 'COPD' named entity 'POLY' named entity 'STIMULATION' named entity 'ANTIVIRAL RESPONSE' named entity 'ASSOCIATED WITH' named entity 'EVIDENCE' named entity 'INFECTION' named entity 'MEASURED' named entity 'MAJOR' named entity 'BRONCHIAL EPITHELIUM' named entity 'CYSTIC FIBROSIS' named entity 'MECHANISMS' named entity 'BRONCHIAL' named entity 'MINOR' named entity 'INTERFERON ' named entity 'RHINOVIRUSES' named entity 'PILOT STUDY' named entity 'COMPARISON' named entity 'LEVEL' named entity 'HEALTHY' named entity 'EPITHELIAL CELLS' named entity 'INDUCTION' named entity 'LEVELS' named entity 'UNDERSTOOD' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'PRRS' named entity 'RESPONSE' named entity 'ASSOCIATED' named entity 'RVS' named entity 'GENES' named entity 'INVOLVEMENT' named entity 'MINOR' named entity 'MAJOR' named entity 'ASTHMA' named entity 'CYSTIC FIBROSIS' named entity 'IFN' named entity 'PATHWAY' named entity 'INTERFERON ' named entity 'TRIGGERED' named entity 'GROUP' named entity 'minor' named entity 'interferon' named entity 'cystic fibrosis' named entity 'Rhinoviruses' named entity 'COPD' named entity 'PRRs' named entity 'Interferon' named entity 'bronchial' named entity 'P. aeruginosa' named entity 'PKR' named entity 'Bronchial' named entity 'MxA' named entity 'viruses' named entity 'parainfluenza virus'

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