About: Threatening drug‐drug interaction in a kidney transplant patient with Coronavirus Disease 2019 (COVID‐19)

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About: Threatening drug‐drug interaction in a kidney transplant patient with Coronavirus Disease 2019 (COVID‐19) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Threatening drug‐drug interaction in a kidney transplant patient with Coronavirus Disease 2019 (COVID‐19)
Creator	Bartoloni, Alessandro Annarita Botta, ; Bagalà, Alfredo Bartiromo, Marilù Borchi, Beatrice Bresci, Silvia Cavallo, Annalisa Cirami, Calogero Cutruzzulà, Roberta Larti, Aida Lugli, Gianmarco Tilli, Marta Vaglio, ; Xhaferi, Brunilda
source	Medline; PMC
abstract	During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long‐term immunosuppressive therapy. For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. We present the case of a 36‐year‐old kidney transplanted woman affected by Senior‐Loken syndrome diagnosed with COVID‐19 pneumonia after a contact with her positive mother. Initial symptoms were fatigue, dry cough and coryza; she never had fever nor oxygen supplementation. Hydroxychloroquine and lopinavir/ritonavir were started, and the antiviral drug was replaced with darunavir/cobicistat after two days for diarrhea. Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction. The patient was left with steroid therapy alone. The peculiarity of clinical presentation and the management difficulties represent the flagship of our case‐report. We stress the need for guidelines in transplant recipients with COVID‐19 infection with particular regard to the management of therapy.
has issue date	2020-04-12(xsd:dateTime)
bibo:doi	10.1111/tid.13286
bibo:pmid	32279418
has license	no-cc
sha1sum (hex)	c174532aef37040e9873f735b31e996a02712fb6
schema:url	https://doi.org/10.1111/tid.13286
resource representing a document's title	Threatening drug‐drug interaction in a kidney transplant patient with Coronavirus Disease 2019 (COVID‐19)
has PubMed Central identifier	PMC7262190
has PubMed identifier	32279418
schema:publication	Transpl Infect Dis
resource representing a document's body	covid:c174532aef37040e9873f735b31e996a02712fb6#body_text
is schema:about of	named entity 'AFFECTED' named entity 'NOVEL CORONAVIRUS' named entity 'REASON' named entity 'manifestations' named entity 'organ transplant' named entity 'susceptible' named entity 'woman' named entity 'pneumonia' named entity 'Affiliation' named entity 'coronavirus pandemic' named entity 'general population' named entity 'overdose' named entity 'pharyngeal' named entity 'respiratory rate' named entity 'immunosuppressive therapy' named entity 'pCO2' named entity 'pneumonia' named entity 'methylprednisolone' named entity 'CRP' named entity 'neutrophil' named entity 'public health' named entity 'immunosuppressive drug' named entity 'inflammatory' named entity 'living-donor' named entity 'trough level' named entity 'toxicity' named entity 'clinical complications' named entity 'ceftriaxone' named entity 'deceased-donor' named entity 'Tuscany' named entity 'antiviral therapy' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'allopurinol' named entity 'tacrolimus' named entity 'Tropical Diseases' named entity 'COVID-19 infection' named entity 'darunavir/cobicistat' named entity 'creatinine' named entity 'SARS-CoV-2' named entity 'lymphocyte count' named entity 'immunosuppressive therapy' named entity 'blood pressure' named entity 'gastrointestinal' named entity 'body temperature' named entity 'inflammatory cytokines' named entity 'mmol' named entity 'COVID' named entity 'trough levels' named entity 'real-time polymerase chain reaction' named entity 'transplant recipients' named entity 'Careggi' named entity 'Italy' named entity 'coronaviruses' named entity 'COVID19' named entity 'lopinavir/ritonavir' named entity 'retinal degeneration' named entity 'antiviral therapy' named entity 'follow-up' named entity 'corticosteroids' named entity 'Lombardy' named entity 'ESKD' named entity 'Coronavirus' named entity 'IL-1beta' named entity 'pneumonia' named entity 'incubation period' named entity 'dry cough' named entity 'Tacrolimus'

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