About: Interfering antiviral immunity: application, subversion, hope?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interfering antiviral immunity: application, subversion, hope?
Creator	Shankar, Premlata Kumar, Priti Lee, Sang Manjunath, N
Source	Elsevier; Medline; PMC
abstract	RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vitro and in vivo in mouse and monkey models. These results have generated profound interest in the use of this technology as a potential treatment strategy for viral infections for which vaccines and drugs are unavailable or inadequate. In this review, we discuss the progress made within the past 2–3 years towards harnessing the potential of RNAi for clinical application in viral infections and the hurdles that have yet to be overcome.
has issue date	2006-06-06(xsd:dateTime)
bibo:doi	10.1016/j.it.2006.05.006
bibo:pmid	16753342
has license	no-cc
sha1sum (hex)	c19351ac98ce8f0c5b22c28707937ce1caf51cc7
schema:url	https://doi.org/10.1016/j.it.2006.05.006
resource representing a document's title	Interfering antiviral immunity: application, subversion, hope?
has PubMed Central identifier	PMC7185794
has PubMed identifier	16753342
schema:publication	Trends Immunol
resource representing a document's body	covid:c19351ac98ce8f0c5b22c28707937ce1caf51cc7#body_text
is schema:about of	named entity 'overcome' named entity 'potential' named entity 'natural' named entity 'ITS' named entity 'VARIETY' named entity 'TOOL' named entity 'RESULTS' named entity 'YEARS' named entity 'NATURAL' named entity 'VIRUSES' named entity 'RNA INTERFERENCE' named entity 'REVIEW' named entity 'TO INHIBIT' named entity 'SEQUENCE' named entity 'ANTIVIRAL' named entity 'IMMUNITY' named entity 'INTERFERING' named entity 'APPLICATION' named entity 'INTEREST' named entity 'ORGANISMS' named entity 'RNAI' named entity 'HOPE' named entity '2-3' named entity 'REPLICATION' named entity 'MONKEY' named entity 'DISCUSS' named entity 'GENERATED' named entity 'MOUSE' named entity 'TREATMENT STRATEGY' named entity 'IN VIVO' named entity 'GENE EXPRESSION' named entity 'PLANTS' named entity 'POTENTIAL' named entity 'INITIALLY' named entity 'VACCINES' named entity 'USE OF' named entity 'DEMONSTRATED' named entity 'VIRAL INFECTIONS' named entity 'UNAVAILABLE' named entity 'MAMMALS' named entity 'SPECIFIC' named entity 'ANTIVIRAL' named entity 'RAPIDLY' named entity 'MECHANISM' named entity 'HAVE' named entity 'IN VITRO' named entity 'PAST' named entity 'MODELS' named entity 'PROFOUND' named entity 'DRUGS' named entity 'OVERCOME' named entity 'CLINICAL APPLICATION' named entity 'TECHNOLOGY' named entity 'PROGRESS' named entity 'SUPPRESS' named entity 'INADEQUATE' named entity 'INCLUDING' named entity 'THESE' named entity 'mechanism' named entity 'RNA interference' named entity 'emerged' named entity 'mammals' named entity 'demonstrated' named entity 'RNA interference' named entity 'viral infections' named entity 'RNAi' named entity 'gene expression' named entity 'vaccines' named entity 'RNAi' named entity 'RNAi' named entity 'Transfecting' named entity 'liposomes' named entity 'miRNA' named entity 'intravenous injection' named entity 'papilloma viruses' named entity 'Herpes simplex virus' named entity 'autocatalytic' named entity 'lentivirus'

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