About: FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation
Creator	Ling, Thai-Yen Lin, Yi Chen, Min-Huey Chen, Rung-Shu Tai, Yun-Yuan
Source	Medline; PMC
abstract	BACKGROUND: Epithelial invagination is important for initiation of ectodermal organogenesis. Although many factors regulate ectodermal organogenesis, there is not any report about their functions in real-time study. Electric cell-substrate impedance sensing (ECIS), a non-invasive, real-time surveillance system, had been used to detect changes in organ cell layer thickness through quantitative monitoring of the impedance of a cell-to-microelectrode interface over time. It was shown to be a good method for identifying significant real-time changes of cells. The purpose of this study is to establish a combined bioengineered organ-ECIS model for investigating the real time effects of fibroblast growth factor-9 (FGF-9) on epithelial invagination in bioengineered ectodermal organs. We dissected epithelial and mesenchymal cells from stage E14.5 murine molar tooth germs and identified the real-time effects of FGF-9 on epithelial-mesenchymal interactions using this combined bioengineered organ-ECIS model. RESULTS: Measurement of bioengineered ectodermal organ thickness showed that Fibroblast growth factor-9 (FGF-9) accelerates epithelial invagination in reaggregated mesenchymal cell layer within 3 days. Gene expression analysis revealed that FGF-9 stimulates and sustains early Ameloblastin and Amelogenin expression during odontogenesis. CONCLUSIONS: This is the first real-time study to show that, FGF-9 plays an important role in epithelial invagination and initiates ectodermal organogenesis. Based on these findings, we suggest FGF-9 can be applied for further study in ectodermal organ regeneration, and we also proposed that the ‘FGF-BMP balancing system’ is important for manipulating the morphogenesis of ectodermal organs. The combined bioengineered organ-ECIS model is a promising method for ectodermal organ engineering and regeneration research.
has issue date	2012-11-23(xsd:dateTime)
bibo:doi	10.1186/1478-811x-10-34
bibo:pmid	23176204
has license	cc-by
sha1sum (hex)	c19b92f638a71bdf631c296aee8d9fbfd4202034
schema:url	https://doi.org/10.1186/1478-811x-10-34
resource representing a document's title	FGF-9 accelerates epithelial invagination for ectodermal organogenesis in real time bioengineered organ manipulation
has PubMed Central identifier	PMC3515343
has PubMed identifier	23176204
schema:publication	Cell Commun Signal
resource representing a document's body	covid:c19b92f638a71bdf631c296aee8d9fbfd4202034#body_text
is schema:about of	named entity 'organogenesis' named entity 'DETECT CHANGES' covid:arg/c19b92f638a71bdf631c296aee8d9fbfd4202034 named entity 'BIOENGINEERED' named entity 'EPITHELIAL' named entity 'REAL-TIME' named entity 'PURPOSE' named entity 'AMELOGENIN' named entity 'TOOTH GERMS' named entity 'IMPEDANCE' named entity 'METHOD' named entity 'DISSECTED' named entity 'MODEL' named entity 'ODONTOGENESIS' named entity 'SENSING' named entity 'EARLY' named entity 'STAGE' named entity 'ORGANOGENESIS' named entity 'THEIR' named entity 'NON-INVASIVE' named entity 'QUANTITATIVE' named entity 'INVAGINATION' named entity 'TO DETECT' named entity 'AMELOBLASTIN' named entity 'USED' named entity 'RESULTS' named entity 'GOOD' named entity 'REPORT' named entity 'INITIATION' named entity 'TIME STUDY' named entity 'INTERFACE' named entity 'REAL TIME' named entity 'MONITORING' named entity 'COMBINED' named entity 'MURINE' named entity 'E14' named entity 'IDENTIFYING' named entity 'INVESTIGATING' named entity 'SUBSTRATE' named entity 'ACCELERATES' named entity 'SURVEILLANCE SYSTEM' named entity 'ELECTRIC' named entity 'EFFECTS' named entity 'FUNCTIONS' named entity 'SIGNIFICANT' named entity 'IMPORTANT' named entity 'STUDY' named entity 'REVEALED' named entity 'REGULATE' named entity 'A CELL' named entity 'DAYS' named entity 'MEASUREMENT' named entity 'USING' named entity 'EXPRESSION' named entity 'GENE EXPRESSION ANALYSIS' named entity 'CELL' named entity 'ABOUT' named entity 'MICROELECTRODE' named entity 'CELL LAYER' named entity 'CELLS' named entity 'ECTODERMAL' named entity 'TIME' named entity 'IDENTIFIED' named entity 'INTERACTIONS' named entity 'FIBROBLAST GROWTH FACTOR-9' named entity 'MESENCHYMAL CELL' named entity 'ORGAN' named entity 'THICKNESS' named entity 'MOLAR TOOTH' named entity 'MESENCHYMAL' named entity 'FGF-9' named entity 'BACKGROUND' named entity 'MESENCHYMAL CELLS' named entity 'ESTABLISH' named entity 'real-time' named entity 'Results' named entity 'growth factor'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software